BLOOD PRESSURE CONTROL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对内源性一氧化氮和β-肾上腺素能受体激动剂有反应的动脉血管舒张受损的原发性高血压患者，对硝酸盐和β-肾上腺素能受体激动剂有反应的通气正常。原发性高血压患者对α受体激动剂有过度的升压反应，对α受体激动剂有正常的静脉收缩反应。低血压和体位性低血压的患者对一氧化氮的反应是动脉和静脉扩张过度。 β-2-肾上腺素能受体和α-1肾上腺素能受体的多态性可以解释对这些药物的药理学反应的部分但非全部变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with essential hypertension who have impaired arterial vasodilation in response to endogenous nitric oxide and beta adrenergic agonists will have normal ventilation in response to nitrates and beta agonists. Patients with essential hypertension have exaggerated pressor responses to alpha agonists will have normal venoconstrictor responses to alpha agonists. Patients with low blood pressure and postural hypotension will have exaggerated arterial and venous dilation in response to nitric oxide. Polymorphisms of the beta-2-adrenergic receptor and alpha-1 adrenergic receptors will explain some but not all of the variations in pharmacological responses to these agents.