DENDRITIC CELLS (DC) CROSSTALK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一建议的主要目的是验证一种假设，即树突状细胞(DC)为基础的刺激所诱导的细胞毒性T淋巴细胞(CTL)对人硫代乙酰胺酸(TAA)的反应中的串扰受到DC-Th串扰的调节。更好地理解DC-Th交叉对话的参与规则将对DC疫苗的设计产生重大影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this proposal is to test the hypothesis that Crosstalk in Cytotoxic T Lymphocytes (CTL) response against human thioacetamide acid (TAA) induced by Dendritic Cells (DC)-based stimulation is subject to regulation by DC-Th cross-talks. A better understanding of the rules of the engagement of DC-Th cross-talks that govern the generation and the control of anti-TAA CTL response will have a major impact in DC-based vaccine design.