A MULTI-CENTER STUDY OF MINOCYCLINE IN ALS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是测试米诺环素(米诺辛)与安慰剂(一种非活性物质)在肌萎缩侧索硬化症患者中的安全性、耐受性和有效性。在四个月的时间里，患者将接受检查和访谈，以确定他们的疾病的自然发展。他们将再接受9个月的治疗，看看美诺辛是否会减缓ALS的进展，而不是安慰剂。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test the safety, tolerability and effectiveness of minocycline (Minocin) compared to placebo (an inactive substance) in patients with amyotrophic lateral sclerosis. For four months, the patients will be examined and interviewed to establish the natural progression of their disease. They will undergo treatment for an additional 9 months to see if Minocin will slow the progression of ALS as compared to placebo.