A MULTI-CENTER STUDY OF MINOCYCLINE IN ALS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是测试米诺环素（米诺环素）与安慰剂（一种非活性物质）相比在肌萎缩侧索硬化症患者中的安全性、耐受性和有效性。在四个月的时间里，患者将接受检查和面谈，以确定其疾病的自然进展。他们将接受额外9个月的治疗，以观察与安慰剂相比，米诺新是否会减缓ALS的进展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test the safety, tolerability and effectiveness of minocycline (Minocin) compared to placebo (an inactive substance) in patients with amyotrophic lateral sclerosis. For four months, the patients will be examined and interviewed to establish the natural progression of their disease. They will undergo treatment for an additional 9 months to see if Minocin will slow the progression of ALS as compared to placebo.