MECHANISMS OF GROWTH HORMONE RESISTANCE IN COLITIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 生长障碍和组织愈合不良是许多患有慢性炎症性疾病（包括炎症性肠病（IBD））的儿童的重要并发症。 Denson博士研究项目的主要重点是确定慢性炎症抑制正常儿童生长和组织愈合的机制。 这些研究涉及患有一种称为克罗恩病的IBD的儿童。 我们正在专门研究慢性炎症阻断生长激素的有益作用，导致生长不良和组织愈合的方式。 相反，我们也在研究生长激素本身的新抗炎作用。 这项工作最近导致了特异性炎症蛋白的鉴定，这些蛋白可以作为新疗法的靶点，以及将生长激素与标准疗法一起使用的潜力。 目前正在进行的克罗恩病儿童研究将确定阻断这些炎症蛋白的有效性。 这项工作应该导致改善儿童IBD的治疗方法，这将优化生长和肠道愈合。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Growth failure and poor tissue healing are significant complications for many children with chronic inflammatory diseases including Inflammatory Bowel Disease (IBD). The primary focus of Dr. Denson's research project is to determine the mechanisms by which chronic inflammation inhibits normal childhood growth and tissue healing. These studies involve children with a type of IBD called Crohn's disease. We are specifically examining the manner in which chronic inflammation blocks beneficial actions of growth hormone, leading to poor growth and tissue healing. Conversely, we are also examining new anti-inflammatory effects of growth hormone itself. This work has recently led to the identification of specific inflammatory proteins which may serve as targets for new therapies, as well as the potential for using growth hormone together with standard therapy. Ongoing studies in children with Crohn's disease will now determine the effectiveness of blocking these inflammatory proteins. This work should lead to improved therapeutic approaches for childhood IBD which will optimize both growth and intestinal healing.