SURGICAL WEIGHT LOSS INTERVENTION IN SLEEP APNEA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 上呼吸道的周期性阻塞是阻塞性睡眠呼吸暂停（OSA）的最常见原因。 发展增加的气道通透性和随后的OSA的最强的危险因素是肥胖。 同样，体重减轻也会降低OSA的严重程度。 到目前为止，尚不清楚体重减轻和OSA改善之间是否存在剂量反应关系。 体重减轻引起的OSA改善所涉及的因素也有待阐明。 本议定书的目标是： 1)确定睡眠呼吸障碍（SDB）与上气道生理、人体测量和代谢参数之间的关联; 2)确定体重减轻程度与 1.睡眠呼吸障碍的严重程度 B）体重减轻后上气道通透性降低 c）其他神经、代谢、人体测量和生理预测因子

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic occlusion of the upper airway is the most common cause of obstructive sleep apnea (OSA). The strongest risk factor for the development of increased airway collapsibility, and consequent OSA, is obesity. Similarly, weight loss is known to decrease the severity of OSA. To date, it is not clear if there is a dose-response relationship between weight loss and improvement in OSA. The factors involved in weight loss-induced improvements in OSA also remain to be elucidated. The goals of the present protocol are to: 1)determine the association between sleep disordered breathing (SDB) and upper airway physiologic, anthropometric and metabolic parameters; 2)determine the relationship between the degree of weight loss and a)the severity of sleep disordered breathing b)decreases in upper airway collapsibility after weight loss c)other neural, metabolic, anthropometric and physiologic predictors