ANTI-IGA ANTIBODIES WITH ADVERSE REACTIONS TO GAMMA GLOBULIN INFUSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 A. 具体目的/目标 1.在波士顿儿童医院进行一项初步研究，探讨IgA缺陷患者血清IgG或IgE抗IgA抗体的存在与原发性免疫缺陷患者丙种球蛋白给药不良反应的发生之间的可能相关性。 2.比较ELISA法与市售被动血凝法和免疫放射法测定IgG抗IgA抗体的结果。 3.检查6个月内抗IgA抗体的持续性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Specific Aims /Objectives 1. To conduct a pilot study at Children's Hospital Boston of a possible correlation between the presence of serum IgG or IgE anti-IgA antibodies in IgA-deficient patients and the occurrence of adverse reactions to gamma globulin administration in patients with primary immunodeficiency. 2. To compare results of ELISA methods for the determination of IgG anti-IgA antibodies with commercially available passive hemaglutination and immunoradiometric methods. 3. To examine the persistence of anti-IgA antibodies over a 6 month period.