METABOLIC CORRELATES OF OBSTRUCTIVE SLEEP APNEA IN OBESE CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肥胖是儿科人群中的常见问题，患病率为16%。阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是一种反复发作的低氧血症，发生在1/3的肥胖儿童中。在成人中，内脏脂肪过多预示着OSAHS和代谢综合征。OSAHS本身与胰岛素抵抗和炎症有关。我们的目标是通过检测胰岛素抵抗、炎症和体脂分布来研究肥胖儿童OSAHS的代谢相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is a common problem in the pediatric population with a prevalence of 16%. Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a pattern of recurrent hypoxemia and occurs in 1/3 of obese children. In adults, visceral adiposity predicts both OSAHS and the metabolic syndrome. OSAHS itself has been associated with insulin resistance and inflammation. Our goal is to investigate the metabolic correlates of OSAHS in obese children by examining insulin resistance, inflammation, and body fat distribution.