Mineralocorticoid receptor blockade: mechanisms of selectivity

类固醇激素醛固酮控制盐分平衡，从而控制血压。它也被证明对心力衰竭有重要作用。虽然阻断醛固酮受体的药物对治疗心力衰竭是有益的，但它们受到肾脏中钾潴留的限制。为了开发组织特异性的醛固酮受体阻滞剂，有必要确定在特定组织中激活和/或阻断受体的机制。

The steroid hormone aldosterone controls salt balance and hence, blood pressure. It also has been shown to have a significant role in cardiac failure. Although drugs that block the aldosterone receptor are beneficial in the treatment of heart failure, they are limited by potassium retention in the kidney. In order to develop tissue-specific blockers of the aldosterone receptor, it is necessary to identify mechanisms by which the receptor can be activated and/or blocked in specific tissues.