Minimal structural strength required in endoluminal devices for aortic aneurysms: mechanisms of rupture when they fail.

动脉瘤性疾病是一种年龄相关的现象。西方人口的平均预期寿命在过去100年里翻了一番，主要是因为闭塞性心血管疾病的死亡人数减少了。由于社区疾病模式的变化，出现了动脉瘤性疾病。这项工作的影响将是改善对腹主动脉瘤的微创、有效的预防，因为80%的腹主动脉瘤破裂将导致死亡。腔内移植提供了一种侵入性小得多的手术，并提供了一种吸引人的、优雅的替代开放手术的方法。这一领域的总体趋势是走向微型化。危险在于，由于缺乏强度而导致的早期失效，以及由于设备耐久性不足而导致的后期失效，结构强度将受到影响。这项申请建议与皇家珀斯医院血管外科、库克R和D(西澳)、高级流体动力学实验室(CSIRO，墨尔本)和卫生服务研究中心(西澳大学)合作开发一项合资企业，以研究腹主动脉动脉瘤所涉及的动态流动力。它将专业知识和设备结合在一起，检查脉动高压环境中作用于腔内支架移植物的作用力，对设计、通畅性、有效性和长期结果的影响。多学科团队为整个澳大利亚和国际上这一发展中的高科技外科领域提供了一种全面的方法。这项研究的好处将直接影响下一代腔内装置和经皮植入的设计和耐用性。虽然澳大利亚处于发展的前沿，但它目前在市场上的地位只能通过进一步的产品开发来维持。

Aneurysmal disease is an age related phenomenon. The mean life expectancy of western populations has doubled in the last 100 years mainly because of the reduction in deaths from occlusive cardiovascular disease. Aneurysmal disease has emerged as a result of the changing pattern of diseases in the community. The impact of this work would be to improve minimally invasive, effective prophylaxis against aneurysm of the abdominal aorta since 80% of those that rupture will result in death. Endoluminal grafting provides a much less invasive procedure and provides an attractive and elegant alternative to open surgery. The general drive in this field is towards miniaturisation. The danger is that structural strengths will be compromised with early failures due to lack of strength; and late failures due to inadequate device durability. This application proposes the development of a collaborative venture with the Department of Vascular Surgery, Royal Perth Hospital, Cook R and D (WA), the Advanced Fluid Dynamics Laboratory (CSIRO, Melbourne) and Centre for Health Services Research (University of WA) to investigate the dynamic flow forces involved in aneurysms of the abdominal aorta. It combines together expertise and facilities to examine the forces acting upon endoluminal stent grafts in pulsatile high pressure environments, the impact on the design, patency, effectiveness and longer-term outcomes. The multidisciplinary team provides a comprehensive approach for this developing area of high technology surgery throughout Australia and internationally. The benefits of this study will directly influence the design and durability of the next generation of endoluminal devices and percutaneous insertions. While Australia is at the forefront of development, its current place in the market can only be maintained by further product development.