STRESS RESPONSE TO NON-WEIGHT BEARING BEDREST

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然已知静止不动是导致不良健康事件发生率的主要压力源，但护士在没有混淆的合并症的情况下研究静止的机会是有限的。将静止状态的压力效应与共病条件的压力效应分离的能力是这项拟议研究的主要优势。这项纵向重复测量研究的主要目的是检查健康志愿者样本中非负重卧床休息随时间的压力反应。第二个目的是检查卧床休息对睡眠模式、疲劳、抑郁、不适和疼痛的影响。卧床休息与住院患者的功能能力下降、抑郁、住院和死亡有关。多项研究发现，由于疾病、创伤或被迫卧床而导致的行动不便是常见的，进入医院的患者中有相当大比例的人会因为卧床休息而经历行动能力下降和管理日常生活活动(ADL)的能力下降。卧床休息并不是一个与静止和非负重有关的孤立事件；而是一个开创性的事件，它开始了一系列需要不断地进行身体、情感和社会调整的经历和条件。对卧床休息的压力反应是对这一系列经历和条件的反应。即使在以前健康的人中，卧床伴随着知觉剥夺也会导致力量、能量和动力的丧失；疲劳和睡眠障碍的增加；不适，以及情绪和昼夜节律的改变。了解在卧床休息期间接受机械负荷替代和补充的健康志愿者以及那些没有接受机械负荷替代和补充的健康志愿者随着时间的推移而发生的心理神经免疫模式的变化，可能会对患有各种慢性衰弱疾病的个人产生深远的影响；并可能导致制定预防性、初级和二级护理干预措施，以防止或推迟卧床休息的不良影响。这项研究将通过检查卧床休息相关症状模式的变化以及健康志愿者样本中HPA和ANS的昼夜模式来扩展对卧床休息影响的认识。在这项研究中，我们将从Peter R.Cavanagh博士研究的健康志愿者样本中招募受试者，该研究题为：使用卧床休息模拟物对骨骼脱矿的在轨运动对策进行定量测试。Cavanagh博士的这项研究由美国国家航空航天局(NASA)赞助，将在生物医学工程系的勒纳研究所和克利夫兰临床综合临床研究中心(GCRC)进行。我们的子研究得到了Cavanagh博士的支持，这项研究的标题是：使用卧床休息模拟物的眼眶运动的定量TES骨脱钙对策。他的研究由美国国家航空航天局(NASA)赞助，将在生物医学工程系的勒纳研究所和克利夫兰临床综合临床研究中心(GCRC)进行。我们的子项研究得到了卡瓦纳博士的支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although immobility is known to be a major stressor that contributes to the incidence of adverse health events, the opportunity for nurses to study immobility in the absence of confounding co-morbid conditions is limited. The ability to isolate the stressful effect of immobility from the stressful effect of co-morbid conditions is the major strength of this proposed study. The primary purpose of this longitudinal repeated measures study is to examine the stress response of non-weight bearing bedrest over time in a sample of healthy volunteers. A secondary purpose is to examine the effect of bed rest on sleep patterns, fatigue, depression, discomfort, and pain. Bed rest has been associated with decline in functional ability, depression, institutionalization, and death in hospitalized patients. Several studies have found that immobility due to disease, trauma, or forced bed rest is a common occurrence, and a significant percentage of patients who enter a hospital will experience a decline in mobility and a reduction in their ability to manage activities of daily living (ADLS) as a direct result of bed rest. Bed rest is not an isolated event related to immobility and non-weight bearing; but rather a seminal event that begins a cascade of experiences and conditions that require constant physical, emotional, and social adjustment. The stress response to bed rest is a reaction to this cascading series of experiences and conditions. Even in previously healthy individuals, bed confinement in conjunction with perceptual deprivation leads to a loss of strength, energy, and motivation; increased fatigue and sleep disturbances; discomfort, and alterations in mood and circadian rhythms. Understanding psychoneuroimmune pattern changes over time in healthy volunteers receiving mechanical load replacement and supplementation during bedrest and those who do not may have profound implications for individuals with a variety of chronic debilitating disorders; and may lead to the development of preventive, primary and secondary nursing interventions to prevent or delay the adverse effects of bedrest. This study will extend knowledge of the effects of bed rest by examining changes in patterns of bed rest related symptoms, as well as diurnal patterns of HPA and ANS activation in a sample of healthy volunteers. In this study, we will recruit subjects from a sample of healthy volunteers enrolled in the Dr. Peter R. Cavanagh study titled: A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analogue. The research by Dr. Cavanagh is sponsored by the National Aeronautics and Space Administration (NASA) and will be performed at the Lerner Research Institute in the Department of Biomedical Engineering and the Cleveland Clinic General Clinical Research Center (GCRC). We obtained support for our sub-study from Dr. Cavanagh study entitled: A Quantitative Tes of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analogue. His research is sponsored by the National Aeronautics and Space Administration (NASA) and will be performed at the Lerner Research Institute in the Department of Biomedical Engineering and the Cleveland Clinic General Clinical Research Center (GCRC). We obtained support for our sub-study from Dr. Cavanagh.