THE EVALUATION OF THE CLINICAL AND GLUCOSE METABOLIC RESPONSE TO ANTIDEPRESSA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 老年抑郁症的治疗是一个重大的临床问题，因为需要长达12周的抗抑郁治疗来确定药物是否有效，而且许多患者在治疗后没有改善。开发一种方法，在进行扩大的临床试验之前确定哪些患者对治疗没有反应，这将是一个有用的临床工具。此外，通过研究临床症状改善的患者，更好地了解抗抑郁药物在大脑中的作用，可能有助于开发更有效的药物。这些考虑是本研究的原动力，该研究旨在测量单次静脉注射抗抑郁药物(西酞普兰)后大脑代谢的变化，然后在口服药物的慢性治疗期间。研究的目的是比较患者和对照组对西酞普兰的急性代谢反应，并测量慢性西酞普兰治疗对患者的代谢影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The treatment of depression in the elderly represents a significant clinical problem in that it takes up to twelve weeks of antidepressant treatment to determine whether the medication is working and many patients fail to improve with treatment. The development of a method to identify patients who will not respond to treatment prior to undertaking an extended clinical trial would be a useful clinical tool. In addition, a better understanding of how antidepressant medications work in the brain by studying patients who improve clinically may help in the development of more effective medications. These considerations were the impetus for the present study designed to measure the changes in brain metabolism after a single, intravenous dose of an antidepressant medication (citalopram) and then, during chronic treatment with the oral medication.The aims of the study are to compare the acute, metabolic response to citalopram in patients to controls and to measure the metabolic effects of chronic citalopram treatment in the patients.