GENE EXPRESSION IN PEDIATRIC ARTHRITIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是建立幼年类风湿性关节炎和幼年脊柱关节病（JRA/JspA）的遗传基础，这是儿童期最常见的慢性关节病。 该方法将使用整合基因组学来确定可能具有遗传基础的3个元素-易感性，临床结果和对治疗的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to establish the genetic basis for juvenile rheumatoid arthritis and juvenile spondyloarthropathy (JRA/JspA), the most common chronic arthropathies of childhood. The approach will use integrated genomics to identify 3 elements that are likely to have a genetic basis-susceptibility, clinical outcome, and responses to treatment.