IMPAIRED REASONING & SOCIAL JUDGE IN FRONTOTEMPORAL LOBAR DEGEN IN ALS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 额颞叶变性(FTLD)在ALS患者中似乎很常见，发病率接近50%。许多研究已经将额叶皮质调节的字母流畅性受损作为ALS患者FTLD的一个标志，认为字母流畅性受损是单词提取过程中后天自我监控缺陷的结果(Abrahams等人，2000)。然而，很少有研究在更全面的水平上考察肌萎缩侧索硬化症和自我监控之间的关系。我们假设，与肌萎缩侧索硬化症相关的FTLD会导致后天社会判断的缺陷，这是因为在解决语言问题的过程中，自我监控的能力减弱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Frontotemporal lobar degeneration (FTLD) in patients with ALS appears to be common, with an incidence approaching 50 percent. Many studies have identified impaired frontal cortical mediated letter fluency as a marker of FTLD in ALS, considering impaired letter fluency to be the result of an acquired deficit in self-monitoring during the word retrieval process (Abrahams et al., 2000). However, few studies had examined the relationship between ALS and self-monitoring on a more comprehensive level. We hypothesized that the FTLD associated with ALS would result in an acquired deficiency in social judgment, due to a diminished capacity for self-monitoring during the process of verbal problem solving.