COBRE: UD: PROJ 2: THE OSTEOARTHRITIC KNEE: A BIOMECHANICAL ANALYSIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的长期目标是确定异常关节接触力和应力在膝关节骨关节炎（OA）发展中的作用。 为了实现这一目标，必须首先实现几个短期目标。 这些目标为拟议的项目提供了框架，并为持续的OA研究奠定了基础。 该项目的五年目标是开发受试者特定的膝关节生物力学模型，该模型对关节几何形状和肌肉激活的受试者间变化敏感，用于估计髌股和胫股接触力学（即，接触力和应力）。 我们的论点是，日常生活活动（ADL）过程中的异常接触力学与膝关节OA的发生和进展相关。 本项目中创建的模型将用于确定进行5种ADL（步行、上下楼梯、坐立和站坐）的健康受试者的接触力和应力的正常范围。 然后，这些数据将用作参考，以评估最近诊断为轻度OA的患者在进行类似运动时是否表现出异常接触力学。 该项目的组织分为两个不同的目标，可概述如下： 目的1：目的1的目的是确定进行5种ADL的健康受试者的髌股和胫股接触力学的正常范围。 目标二：确定大于正常髌股和胫股接触力学是否是疾病早期OA膝关节的特征。 将使用目标1中概述的方法估计近期诊断为轻度OA但尚未出现慢性症状的个体的关节接触力学。 我们的假设是，早发性OA患者的接触力和压力大于进行类似ADL的健康个体。 在这些患者中显示出大于正常的接触力和应力将支持我们的假设，即异常接触力学与膝关节OA的发作和进展相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of this research is to determine the role that abnormal joint contact forces and stresses contribute to the development of osteoarthritis (OA) of the knee. To achieve this goal, several shorter-term goals must first be realized. These goals provide the framework for the proposed project and the foundation for continued OA research. The five year goal of this project is to develop subject specific biomechanical models of the knee that are sensitive to inter-subject variations in joint geometry and muscle activations for the purposes of estimating patellofemoral and tibiofemoral contact mechanics (i.e., contact forces and stresses). It is our thesis that abnormal contact mechanics during activities of daily living (ADLs) are associated with the onset and progression of knee OA. The models created in this project will be used to establish normal ranges of contact force and stress for healthy subjects performing 5 ADLs (walking, stair ascent & descent, sit-to-stand & stand-to-sit). These data will then be used as a reference to assess if patients recently diagnosed with mild OA exhibit abnormal contact mechanics while performing similar movements. The organization of this project is divided into two distinct aims and may be summarized as follows: Aim 1: The goal of Aim 1 is to define normal ranges of patellofemoral and tibiofemoral contact mechanics for healthy subjects performaing the 5 ADLs. Aim 2: To determine if larger than normal patellofemoral and tibiofemoral contact mechanics are characteristic of the OA knee during the early stages of the disease. Joint contact mechanics for individuals recently diagnosed with mild OA, but not yet chronically symptomatic will be estimated using the approach outlined in Aim 1. It is our hypothesis that individuals with early onset OA will have larger contact forces and stresses than healthy individuals performing similar ADLs. Showing larger than normal contact forces and stresses in these patients would support our hypothesis that abnormal contact mechanics are associated with the onset and progression of knee OA.