THE PROGRESSION OF OSTEOARTHRITIS AND ALTERED MUSCLE COORDINATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 膝关节骨关节炎（OA）的进展导致关节软骨恶化，最终可能需要手术干预以缓解关节疼痛并使日常生活活动正常进行。 肌肉协调模式的适应可能是对疼痛的反应，随着疾病的进展，步态偏差变得更加明显。 拟议的研究旨在研究OA进展过程中肌肉协调模式的演变，将协调模式的变化与步态的变化联系起来，并确定这些变化是否有效地减少了膝关节的负荷。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The progression of knee osteoarthritis (OA) results in deterioration of articular cartilage and may ultimately necessitate surgical intervention to alleviate joint pain and enable normal performance of activities of daily living. Adaptations to muscle coordination patterns occur presumably in response to pain and gait deviations become more pronounced as the diseases progresses. The proposed study is designed to investigate the evolution of muscle coordination patterns during the progression of OA, to relate changes in coordination patterns to changes in gait, and to determine whether these changes effectively reduce loads at the knee.