RISK FACTORS FOR PROGRESSION OF OSTEOARTHRITIS OF THE KNEE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 膝关节OA的原因尚不清楚，但很可能是生物力学因素导致了受影响软骨和骨的异常负荷。有效的非手术干预是有限的，可能包括加强，锻炼和使用手杖或矫正器，但肌肉活动可能是最重要的可改变因素。本研究旨在研究年龄相关性膝关节骨关节炎患者步态过程中的肌肉力量和协调策略。这将通过MRI、步态分析、肌电图和生物力学建模和模拟的组合来完成。本项目将建立在项目4所预测的临床基础之上，该项目采用临床方法探索TKA后OA的进展。布坎南博士将担任科学导师，斯奈德-麦克勒博士将担任职业导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Causes of knee OA are unknown, but it is likely that biomechanical factors contribute to abnormal loading on the affected cartilage and bone. Effective non-surgical interventions are limited and may include strengthening, exercise and use of a cane or orthotic, but muscle activity may be the most significant modifiable factor. The proposed study is designed to investigate muscle forces and coordination strategies during gait in individuals with age-related osteoarthritis of the knee. This will be done thought a combination of MRI, gait analysis, electromyography, and biomechanical modeling and simulation. This project will build upon the clinical foundation projected by project #4, which takes a clinical approach to explore the progression of OA following TKA. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.