RISK FACTORS FOR PROGRESSION OF OSTEOARTHRITIS OF THE KNEE

膝骨关节炎进展的危险因素

• 批准号: 7959492
• 负责人: Jill S Higginson
• 金额: $ 29.02万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959492
• 关键词: Affect; Biomechanics; Canes; Cartilage; Centers of Research Excellence; Clinical; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Electromyography; Engineering; Exercise; Foundations; Funding; Gait; Grant; Individual; Institution; Knee; Knee Osteoarthritis; Magnetic Resonance Imaging; Mentors; Muscle; Operative Surgical Procedures; Research; Research Personnel; Resources; Risk Factors; Science; Source; United States National Institutes of Health; Woman; age related; bone; career; design; gait examination; models and simulation; orthotics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Causes of knee OA are unknown, but it is likely that biomechanical factors contribute to abnormal loading on the affected cartilage and bone. Effective non-surgical interventions are limited and may include strengthening, exercise and use of a cane or orthotic, but muscle activity may be the most significant modifiable factor. The proposed study is designed to investigate muscle forces and coordination strategies during gait in individuals with age-related osteoarthritis of the knee. This will be done thought a combination of MRI, gait analysis, electromyography, and biomechanical modeling and simulation. This project will build upon the clinical foundation projected by project #4, which takes a clinical approach to explore the progression of OA following TKA. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 膝关节骨关节炎的原因尚不清楚，但很可能是生物力学因素导致了受影响的软骨和骨骼上的异常负荷。有效的非手术干预是有限的，可能包括加强、锻炼和使用拐杖或矫形器，但肌肉活动可能是最重要的可改变因素。这项拟议的研究旨在调查与年龄相关的膝骨性关节炎患者在步态过程中的肌力和协调策略。这将通过结合核磁共振、步态分析、肌电和生物力学建模和模拟来完成。这个项目将建立在项目#4计划的临床基础上，该项目采用临床方法来探索全膝关节置换术后骨性关节炎的进展。布坎南博士将担任科学导师，斯奈德-麦克勒博士将担任职业导师。