Study of Secondary Conditions and Effects of Aquatic Intervention on Adult CP

描述(由申请者提供)：这个有指导的研究职业发展奖将培训Deborah Thorpe博士进行临床结果研究。长期目标是让她为独立资助的、假设驱动的研究做好准备，这些研究将测试旨在保持成年脑瘫(CP)患者的机动性、活动度和生活质量的干预措施。索普博士是北卡罗来纳大学物理治疗部联合健康科学系的助理教授。她的主要导师是理查德·亨德森博士，他是一位知名的骨科医生，也是CP肌肉骨骼疾病领域的研究人员。索普博士的合作导师是玛格丽特·特克博士，他是纽约州立大学北部医科大学著名的物理医学和康复临床医生兼科学家，主要研究衰老对CP患者的影响。该申请提出了一种教学和临床研究相结合的体验，将利用北卡罗来纳大学教堂山分校和纽约州立大学北部医科大学的大量资源来培养索普博士对临床结果研究和基于活动的干预的兴趣。Dianne Damiano博士、Carol Giuliani博士、Robert McMurray博士和Laura Vogtle博士也将在CP和成果研究的主题领域提供研究建议和专业知识。 提出了由两部分组成的指导性研究计划。关于继发性损害的发展和当前干预措施的有效性的证据很少，这些干预措施旨在解决成年CP患者的活动、活动和健康相关生活质量(HRQL)问题。为了解决这些循证实践中的局限性，本研究的具体目的是：(1)确定成人脑性瘫痪队列中继发性损害和非损害相关因素的特征。(1B)描述脑性瘫痪成人队列中继发性损害、HRQL与活动和活动水平之间的关系。(2)确定水中运动干预的可行性，目的是减轻所选继发性损害的严重程度，改善成人脑瘫队列的HRQL和活动水平。目标1a和1b将收集人口统计信息，并测量身体成分、力量、疼痛、心肺健康状况和与健康相关的生活质量(HRQL)，以便更好地确定将成为未来研究重点的具体损害、功能限制和残疾。目的2建立纵向水上阻力运动干预的可行性，评价其对力量、疼痛、心肺适能、活动水平、运动经济性和HRQL的影响。预计水上阻力运动将有助于增加力量、减轻疼痛和改善心肺健康，从而提高与健康相关的生活质量。

DESCRIPTION (provided by applicant): This mentored research career development award will train Dr. Deborah Thorpe in clinical outcomes research. The long term goal is to prepare her for independently funded, hypothesis-driven investigations that will test interventions designed to maintain mobility, activity and quality of life in adults with cerebral palsy (CP). Dr. Thorpe is an Assistant Professor at UNC in the Department of Allied Health Sciences, Division of Physical Therapy. Her primary mentor is Dr. Richard Henderson, an established orthopedic surgeon and researcher in the area of musculoskeletal conditions in CP. Dr. Thorpe's co-mentor is Dr. Margaret Turk, an established physical medicine and rehabilitation clinician-scientist from SUNY Upstate Medical University whose research focuses on the effects of aging in persons with CP. The application proposes a combined didactic and clinical research experience that will utilize the vast resources at the University of North Carolina at Chapel Hill as well as SUNY Upstate Medical University to foster Dr. Thorpe's demonstrated interest in clinical outcomes research and activity-based intervention. Drs. Dianne Damiano, Carol Giuliani, Robert McMurray and Laura Vogtle will also provide research advisement and expertise in the subject areas of CP and outcomes research. A two-part mentored research plan is proposed. There is a paucity of evidence addressing the development of secondary impairments and the efficacy of current interventions to address mobility, activity, and health related quality of life (HRQL) in adults with CP. To address these limitations in evidenced-based practice, the specific aims of this study are to: (1a) Characterize secondary impairments and nonimpairment-related factors in a cohort of adults with CP. (1b) Describe the relationships among secondary impairments, HRQL and activity and mobility levels in a cohort of adults with CP. (2) Determine the feasibility of an aquatic exercise intervention aimed at diminishing the severity of select secondary impairments and improving HRQL and activity level in a cohort of adults with CP. Aims 1a and 1b will collect demographic information and measure body composition, strength, pain, cardiorespiratory fitness and health related quality of life (HRQL) in order to better identify specific impairments, functional limitations and disability that will be the focus of future study. Aim 2 will establish the feasibility of a longitudinal aquatic resistive exercise intervention and evaluate its effects on strength, pain, cardiorespiratory fitness, activity level, economy of movement and HRQL. It is expected that aquatic resistive exercise will facilitate increased strength, reduced pain and improved cardiorespiratory fitness, thereby improving health related quality of life.