UCLA OLDER AMERICANS INDEPENDENCE CENTER

成立于1991年，加州大学洛杉矶分校克劳德D。胡椒老年美国人独立中心（UCLA OAIC） 寻求第三次更新，以继续其扩大科学知识的使命，这将导致更好的 保持或恢复独立性。 在这次更新中，我们将把我们的努力集中在“发展干预措施以保持独立性”这一主题上 和理解成功干预的机制，“这扩展了该中心的先前研究。 因此，重点将放在建立基础生物医学科学和临床之间桥梁的研究上。 科学在加州大学洛杉矶分校OAIC范式，基础生物医学研究通知临床研究和临床 研究为基础生物医学研究提供信息。因此，UCLA OAIC将支持以下研究： 这两种类型的研究，在两个方向1）检查机制的基础上成功的临床 2）开发新的基础科学方法，这将导致临床干预。 该中心将通过4个研究核心（招募，研究运营， 分析和成本效益，炎症生物学），试点和探索性研究（P/EC）核心， 研究职业发展核心（RCDC）和领导/行政核心（LAC）。研究 核心将提供4个级别的支持（咨询、短期、持续和新项目的伙伴关系）， 外部项目（例如，R 01）和内部审计和信息中心活动（例如，飞行员和职业发展奖获得者）。 UCLA OAIC将通过实现6个具体目标来实现其目标： 1)为老年医学和老龄化研究提供智力领导和创新， 主题及相关研究 2)促进基础和临床研究之间的转化联系，重点是 炎症 3)促进和发展新的多学科研究 4)鼓励采用新兴技术 5)为其他机构提供意见和合作 6)为未来的研究领导者提供职业发展

Established in 1991, the UCLA Claude D. Pepper Older Americans Independence Center (UCLA OAIC) seeks a third renewal to continue its mission of expanding the scientific knowledge that will lead to better ways to maintain or restore independence. In this renewal, we will focus our efforts on the theme, "Developing Interventions to Maintain Independence and Understanding Mechanisms of Successful Interventions," which extends the Center's prior research. Thus, the emphasis will be on research that builds bridges between basic biomedical science and clinical science. In the UCLA OAIC paradigm, basic biomedical research informs clinical research and clinical research informs basic biomedical research. Accordingly, the UCLA OAIC will support research that links these two types of research in both directions by 1) examining mechanisms underlying successful clinical interventions and 2) developing new basic science approaches that will lead to clinical interventions. The Center will stimulate scientific discovery through 4 Research Cores (Recruitment, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies (P/EC) Core, a Research Career Development Core (RCDC), and a Leadership/Administrative Core (LAC). Research Cores will provide 4 levels of support (consultation, short-term, ongoing, and partnership on new projects) for external projects (e.g., R01s) and internal OAIC activities (e.g., pilots and Career Development Awardees). The UCLA OAIC will accomplish its goals by accomplishing 6 Specific Aims: 1) To provide intellectual leadership and innovation for geriatrics and aging research on the Center's theme and related research 2) To stimulate translational links between basic and clinical research, with an emphasis on inflammation 3) To facilitate and develop novel multidisciplinary research 4) To stimulate incorporation of emerging technologies 5) To serve as source of advice and collaboration to other institutions 6) To provide career development of future research leaders