RESEARCH CORE

研究核心 研究项目概述 为NCCU的NCMHD研究中心提出的研究核心将设在JLC-BBRI， 将利用研究所的现有资源，同时加强与 由EXPORT P20 Center Grant提供。拟议研究核心的主要目标是 加强和扩大现有的伙伴关系倡议，重点是少数群体的健康差距。过去 四（4）年，一个由各出口中心组成部分的领导组成的行政团队 沿着来自合作学术机构的共同领导人协助PI设计和 执行中心的研究计划。这些计划在以下方面取得了显著的成功： 推进中心设想的议程。大约三（3）个月前，行政部门 团队协助出口中心PI哈尔伍德博士对中心的项目进行年度评估， 各组成部分的领导人被要求准备和提交进度报告，供计划审查 领导所有进度报告都必须包括未来规划一节。这些规划部门 为2006年8月开始的讨论提供了一个框架，当时一个全面的规划进程 启动了管理此更新申请的准备工作。一个规划委员会正式 是为了推动这一进程。它包括JLC-BRI研究项目主任，现有的 出口中心计划组件，以及合作学术机构的共同领导人。这 委员会帮助确定了下文所述的研究核心计划。它有助于发展 选择完整研究项目的标准，并确定共享资源的适当性 核心和试点项目将被纳入P20应用程序。规划过程涉及的问题包括： 如： 拟议的研究项目是否适合解决少数群体的健康差异需求; 确定待调查的具体假设的初步数据的可靠性; NCCU研究团队成员及其合作机构合作者的专业知识; 将拟议项目与探索性的NCMHD中心的专题重点相结合; 教师/学生发展的潜力; 项目组成员持续参与涉及重复研究的可能性 收集遗传和表型数据;以及 产生同行评审的出版物和有价值的赠款申请的可能性。 在此基础上，该伙伴关系将发起一项重大研究倡议，其中将包括全面的研究项目 关于压力、心血管疾病和前列腺癌的研究。这两种疾病都是主要的健康差距疾病 NCCU的科学家和他们的合作者有能力进行调查。试点项目和共享 资源核心被选中以补充研究计划。将处理的问题包括： 遗传易感性、营养和基因/环境相互作用。研究中心的活动包括 旨在：扩大NCCU的基础设施和能力，进行健康差异研究;参与NCCU 学生在健康差距研究;刺激和促进教师和学生交流;并通过 研讨会、焦点小组会议和正式研讨会的赞助增加了学生、教师和 提高社区对心血管疾病和癌症的认识。虽然大多数拟议的研究将是 在JLC-BBRI设备齐全的实验室中进行，该中心的活动预计将扩大 在2007年BRITE设施投入使用时，这一点将大大提高。这座新建筑将连接到 125，000平方米英尺新的科学综合体将增加约65，000平方米。英尺研究和教学空间 大学的基础设施。到目前为止，有23个研究活跃的教师进行健康差距 JLC-BBRI的研究。研究核心的每个组成部分的说明如下。

RESEARCH CORE Overview of Research Projects The Research Core proposed for NCCU's NCMHD Research Center will be housed in the JLC-BBRI where it will draw on the Institute's available resources, while building on the strengths of the Core developed with funds provided by the EXPORT P20 Center Grant. A primary objective of the proposed Research Core will be to strengthen and expand existing partnership initiatives that focus on minority health disparities. Over the past four (4) years, an administrative team composed of the leadership of the various EXPORT Center components along with their co-leaders from collaborating academic institutions has assisted the PI with designing and implementing the Center's research programs. These programs have been remarkably successful in advancing the agenda envisioned for the Center. Approximately three (3) months ago, while,the administrative team was assisting the EXPORT Center PI Dr. Harewood with the annual evaluation of the Center's programs, component leaders were instructed to prepare and present progress reports for review by the program leadership. All progress reports were required to include a future planning section. These planning sections have provided a framework for discussions initiated in August 2006 when a comprehensive planning process was initiated to manage the preparation of this renewal application. A Planning Committee was formally established to drive this process. It included the JLC-BRI Research Program Directors, directors of existing EXPORT Center Program Components, and co-leaders from collaborating academic institutions. This Committee has helped to define the plan for the research core that is described below. It helped to develop the criteria for selecting the full research projects, and to determine the appropriateness of the shared resource cores and pilot projects to be included in the P20 application. The planning process addressed issues such as: ¿ appropriateness of the proposed research project for addressing a minority health disparity need; ¿ reliability of preliminary data to identify a specific hypothesis to be investigated; ¿ expertise of the NCCU research team members and their collaborators from partnering institutions; ¿ alignment of the proposed project with the thematic focus of the exploratory NCMHD Center; ¿ potential for faculty/student development; ¿ likelihood of sustained participation by project team members in conducting research involving repeated collection of genetic and phenotypic data; and ¿ probability of yielding peer-reviewed publications and meritorious grant applications. Based on this input, the partnership will launch a major research initiative that will include full research projects on stress and cardiovascular disease and prostate cancer. Both of these are major health disparity diseases that NCCU scientists and their collaborators are competent to investigate. The pilot projects and shared resource cores were selected to complement the research programs. Issues that will be addressed include: genetic predisposition, nutrition, and gene/environment interactions. The activities of the Research Core are designed to: expand NCCU's infrastructure and capacity to conduct health disparities research; involve NCCU students in health disparities research; stimulate and promote faculty and student exchanges; and through sponsorship of workshops, focus group meetings, and formal seminars increase student, faculty, and community awareness of .cardiovascular disease and cancer. While most of the proposed research will be conducted in the well-equipped laboratories of the JLC-BBRI, the Center's activities are projected to expand significantly when the BRITE facility becomes available in 2007. This new building which will be connected to the 125,000 sq. ft. new science complex will add approximately 65,000 sq. ft. of research and teaching space to the university's infrastructure. To date, there are 23 research-active faculty conducting health disparities research in the JLC-BBRI. A description of each of the components of the Research Core is presented below.