NEUROSCIENCE CORE

内侧隔和对角带（内侧隔区）是基底前脑的一个分区， 尤其是老年痴呆症。内侧隔区包含一个 神经元的异质群体，包括胆碱能和非胆碱能投射神经元， 中间神经元。尽管来自隔神经元群的输入对于正常的处理是必要的， 海马和新皮层网络的信息，只有解剖学上的碎片信息， 大多数隔神经元群的电生理学和药理学（胆碱能细胞是隔神经元群的主要神经元）。 例外）目前可用。此外，隔神经元群的连通性及其 随着老化的改变基本上是未知的。这项提案致力于识别突触连接 在隔神经元中，通过这些连接建立的功能回路以及对 隔突触连接所提出的实验将有助于正常和年龄改变的模型 中隔连通性它们还可能导致专门用于调节认知过程的治疗策略 并减轻与年龄有关的疾病，特别是阿尔茨海默病的负担。实验 本提案中所述战略还将为机构内和机构间 合作和新的职业发展机会UTB/TSC教师。

The medial septum and diagonal bands (medial septal region) is a division of the basal forebrain that is affected by aging and in particular by Alzheimer's disease. The medial septal region contains a heterogeneous population of neurons, including cholinergic and non-cholinergic projection neurons and interneurons. Even though inputs from septal neuronal populations are necessary for the normal processing of information by hippocampal and neocortical networks, only fragmented information on the anatomy, electrophysiology and pharmacology of most septal neuronal populations (cholinergic cells are the exception) is currently available. In addition, the connectivity of septal neuronal populations and their alteration with aging is fundamentally unknown. This proposal is dedicated to identify synaptic connections among septal neurons, the functional circuits established through these connections and the aging effect on septal synaptic connectivity. The proposed experiments will facilitate the modeling of normal and age-altered septal connectivity. They also may result in therapeutic strategies dedicated to modulate cognitive processes and alleviate the burden of age-related disorders, in particular Alzheimer's disease. The experimental strategy delineated in this proposal will also provide strong opportunities for intra- and inter-institutional collaborations and new career development opportunities for UTB/TSC faculty.