Computational Modeling for Dialysis Access Surgical Planning

描述（由申请人提供）：这项工作的长期目标是制定一个手术计划包，以帮助透析通路的术前和术后管理。该包将包括一个超声成像系统，提供三维解剖和流速信息，以及一个流体结构相互作用模型。计算模型将利用解剖和血流速度信息进行治疗前计划，预测治疗后结果，以及计算得出的血流动力学参数与治疗后反应的相关性。从长远来看，成像和分析包将允许外科医生在手术前虚拟测试透析通道配置。该手术计划包预计将增加通路的使用寿命，减少需要二次干预的透析通路手术病例的数量，从而改善患者的预后并降低成本。由于这个包是基于超声波的，它是非侵入性的，可以安全和经济有效地跟踪病人一段时间。我们已经开发了超声成像能力来支持这个项目；因此，该基金的重点是流体结构相互作用模拟的发展。

DESCRIPTION (provided by applicant): The long term goal of this work is to develop a surgical planning package to aid in the pre-operative and post-operative management of dialysis access sites. The package will consist of an ultrasound imaging system that provides 3D anatomical and flow velocity information, and a Fluid Structure Interaction model. The computational model will utilize the anatomical and flow velocity information for pre-treatment planning, prediction of post-treatment outcome, and correlation of post-treatment response with the computationally-derived hemodynamic parameters. In the long-term, the imaging and analysis package will allow a surgeon to virtually test dialysis access configurations prior to the surgical procedure. This surgical planning package is expected to increase the lifetime of access sites and reduce the number of dialysis access surgery cases that require secondary intervention, thereby improving patient outcomes and reducing costs. Since this package is ultrasound based, it is non-invasive and can safely and cost-effectively follow patients over time. We have already developed the ultrasound imaging capabilities to support this project; therefore this grant is focused on the development of the Fluid Structure Interaction simulation. PUBLIC HEALTH RELEVANCE: The long term goal of this work is to develop a surgical planning package to aid in the pre-operative and post-operative management of dialysis access sites. Since this planning package will be entirely based on ultrasound imaging, it is non-invasive, safe and cost-effective. This surgical planning package is expected to increase the lifetime of access sites and reduce the number of dialysis access surgery cases that require secondary intervention, thereby improving patient outcomes and reducing costs.