ADMINISTRATIVE CORE

管理核心的职责是协调计划内的科学协作 确保在项目和核心之间适当地转移组织和评价数据，并 将数据发送给对前额叶皮层(PFC)电路的计算建模感兴趣的研究人员 老化的大脑。行政核心将促进项目和核心之间的科学合作 通过午餐时间的定期会议。这个PO1汇集了大脑皮层电生理学的专家， 细胞内信号、神经解剖学、高级认知功能和皮质建模，以应对 来自多学科方法的大脑皮质回路老化问题。我们一直渴望与朱尼尔配对 调查人员配备更多资深科学家，将新科学家引入老龄化研究领域。P01是 高度互动性，取决于共享的资源和对脑组织的多层次分析。一位少校 核心的责任是整合项目和核心之间的数据。来自项目的主题内数据 2-4和组织学和动物核心将被送入行政核心进行多变量分析 我们的统计学家迪皮特罗博士。我们将确定网络实力、工作记忆、树突完整性 分子签名相互作用，改变老化大脑的认知能力。此PO1的调查结果将 提供给王晓静博士，用于PFC网络老化效应的计算建模。王博士 是PFC工作记忆网络计算模型方面的专家，研究如何调节 影响力使PFC网络能够抵抗分心。因此，来自该PO1的数据，特别是 项目1和项目3的电生理发现将与这一努力直接相关。致我们的 知识，这将是第一次将老化的影响包括在一个计算模型中 一等兵。最后，来自该PO1的相关数据将发布在Senselab数据库上，以便与 神经科学界。我们很幸运有Senselab创始人戈登·谢泼德博士担任 这一管理核心的顾问。Senselab包括几个链接到协会的数据库 用于神经科学数据库网关。因此，在本PO1中获得的关于PFC网络老化的发现 将会被感兴趣的神经学家轻易获得。层层摘要：行政核心意志 协调项目和核心，整合数据以进行统计分析，并与其他科学家共享数据。

The responsibilities of the Administrative Core are to coordinate scientific collaboration within the program project, to ensure the proper transfer of tissue and evaluation of data between Projects and Cores, and to deseminate data to researchers interested in computational modeling of prefrontal cortical (PFC) circuits in the aging brain. The Administrative Core will faciltate scientific collaboration between Projects and Cores through regular lunchtime meetings. This PO1 brings together experts in cortical electrophysiology, intracellular signaling, neuroanatomy, higher cognitive function, and cortical modeling in order to tackle the problem of aging cortical circuits from a multi-disciplinary approach. We have aspired to pair junior investigators with more senior scientists to introduce new scientists to the field of aging research. The P01 is highly interactive, depending on shared resources and multi-level analysis of brain tissue. A major responsibility of the Core is integrating data between Projects and Cores. Within-subjects data from Projects 2-4 and the Histology and Animal Cores will be fed into the Administrative Core for multi-variate analysis by our statistician, Dr. DiPietro. We will determine how network strength, working memory, dendritic integrity and molecular signatures interact to alter cognitive abilities in the aging brain. The findings from this PO1 will be provided to Dr. Xiao-Jing Wang for computational modeling of aging effects on PFC networks. Dr. Wang is an expert on computational models of PFC working memory networks, examining how modulatory influences allow PFC networks to resist distraction. Thus, the data from this PO1, particularly the electrophysological findings from Projects 1 and 3, will be of immediate relevance to this endeavor. To our knowledge, this will be the first time that the effects of aging will be included in a computational model of the PFC. Finally, relevant data from this PO1 will be posted on the Senselab database for sharing with the neuroscience community. We are fortunate to have Dr. Gordon Shepherd, the founder of Senselab, as consultant to this Administrative Core. Senselab includes several databases which are linked to the Society for Neuroscience Database Gateway. Thus, the findings gained in this PO1 on the aging of PFC networks will be readily available to interested neuroscientists. LAY SUMMARY: The Administrative Core will coordinate Projects and Cores, integrate data for statistical analysis and share data with other scientists.