Administrative Core

行政核心的目标有两个。首先，作为核心领导，Knipe博士将提供计划 领导协调重组单纯疱疹病毒载体的构建和鉴定与研究 小鼠和恒河猴系统中的载体，决定哪些重组载体在恒河猴身上进行测试 猕猴，决定构建表达HIV基因的重组载体作为临床候选 试验，以及关于向NIAID建议用于临床试验的重组载体的决定。第二，丽莎·霍利克女士 计划管理员，将为会议、数据共享等计划活动提供行政支持 计划、奖助金管理和材料运输。 计划领导力。Knipe博士将协调两个项目和方案中的两个核心努力 设计并检测表达SIV和HIV蛋白的HSV重组体作为艾滋病疫苗载体。因此， 在项目1中努力构建新的载体以增加细胞培养中的表达并增加 小鼠的免疫原性将与恒河猴的免疫原性和保护研究相协调。 Knipe博士将领导每月与Kaur博士和Desrosiers博士的会议，以协调 项目和核心。Knipe博士将在与Kaur博士和Desrosiers博士协商后做出决定， 媒介从小鼠研究转移到恒河猴研究。修改后的矢量显示出5倍的增长 将使用Gag特异性CD8+T细胞反应或env特异性抗体反应来表达SIV蛋白 并用于恒河猴的研究。此外，Knipe博士将决定哪些载体 被选择用于临床试验的开发和生产。 行政支持。行政核心将安排计划会议，准备报告和 手稿，准备数字和Powerpoint演示文稿，订购材料，处理信件， 编制预算，协助核算和报告项目拨款的成本和资金，管理 运送病毒，并实施数据共享计划。该计划的行政支持职能 将由微生物系行政助理Lisa Holik女士执行 哈佛医学院的分子遗传学。

The goals of the Administrative Core are two-fold. First, Dr. Knipe, as Core Leader, will provide program leadership in coordinating the construction and characterization of recombinant HSV vectors with studies of the vectors in murine and rhesus systems, decisions on which recombinant vectors are tested in rhesus macaques, decisions on constructing recombinant vectors expressing HIV genes as candidates for clinical trials, and decisions on proposing recombinant vectors to NIAID for clinical trials. Second, Ms. Lisa Holik, as Program Administrator, will provide administrative support for program activities such as meetings, datasharing program, grants management, and shipping of materials. Program Leadership. Dr. Knipe will coordinate the two projects and two cores in the program efforts to design and test HSV recombinants expressing SIV and HIV proteins as AIDS vaccine vectors. Thus, the efforts in Project 1 to construct new vectors to increase expression in cell culture and to increase immunogenicity in mice will be coordinated with studies of immunogenicity and protection in rhesus macaques in Project 2. Dr. Knipe will lead monthly meetings with Drs. Kaur and Desrosiers to coordinate the projects and cores. Dr. Knipe will make decisions, in consultation with Drs. Kaur and Desrosiers, on which vectors are moved from murine studies to rhesus studies. Modified vectors that show 5-fold increases in gag-specific CD8+ T cell responses or env-specific antibody responses will be used to express SIV proteins and used for studies in rhesus macaques. Furthermore, Dr. Knipe will make decisions about which vectors are chosen for consideration for development and production for clinical trials. Administrative Support. The Administrative Core will arrange program meetings, prepare reports and manuscripts, prepare figures and Powerpoint presentations, order materials, handle correspondence, prepare budgets, assist in the accounting and reporting of costs and funds from the program grant, manage shipping of viruses, and conduct the data-sharing plan. The administrative support functions for the program will be performed by Ms. Lisa Holik, administrative assistant in the Department of Microbiology and Molecular Genetics at Harvard Medical School.