CRYSTALLOGRAPHIC STUDIES OF GLUTAMINE SYNTHETASE AND TNRA FROM BACILLUS SUBTILIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 细菌细胞具有非凡的能力，可以感知和应对环境中的各种变化。 这些细胞需要检测并正确应对极端变化，例如必需营养素的急剧变化。 一种非常重要的营养素是氮，它是生产DNA、蛋白质氨基酸和许多其他细胞元素的关键元素。 大多数细菌使用氨基酸谷氨酰胺作为环境中氮可用性的代谢信号。 反过来，从谷氨酸和氨产生谷氨酰胺的酶，谷氨酰胺合成酶（GS），是氮限制生长期间调节的主要目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial cells have an extraordinary ability to sense and respond to various changes in their environment. These cells need to detect and correctly respond to extreme variations, such as a dramatic change in essential nutrients. One very important nutrient is nitrogen, which is a key element in the production of DNA, amino acids for proteins, and many other cellular elements. Most bacteria use the amino acid glutamine as a metabolic signal for availability of nitrogen in the environment. In turn, the enzyme that produces glutamine from glutamate and ammonia, glutamine synthetase (GS), is the major target of regulation during nitrogen-limited growth.