MONTE CARLO ALGORITHM FOR VIRUS PARTICLE RECONSTRUCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 开发了用于二十面体病毒颗粒重建的SAVR软件包。该软件成功地解决了几种亚纳米级的病毒颗粒结构。正在不断改进，以使其更加强大和普遍。我们正在探索使用蒙特卡罗算法来提高粒子取向搜索和细化的效率和精度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SAVR software package was developed for icosahedral virus particle reconstruction. This software has sucessfully solved several virus particle structures to sub-nanometer resolution. Continuous improvements are being made to make it more robust and universal. We are exploring the use of Monte Carlo algorithm to improve the efficiency and accuracy of the particle orientation search and refinement.