MAGNETIC FIELD EFFECTS IN CRYPTOCHROME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 有人建议 磁罗盘感测 可能是由蓝光受体蛋白隐花色素介导的。最近对植物幼苗的实验表明，拟南芥隐花色素的活性通过弱外部磁场的存在而增强，证实了隐花色素具有磁场响应的能力。 此外，在鸟类的视网膜细胞中发现了隐花色素，已知其在定向行为期间是活跃的。 隐色素s信号是由内部结合的发色团，黄素腺嘌呤二核苷酸（FAD）的光还原调节。 这个光还原过程的自旋化学，其中涉及电子转移从一个链的三个电子，调制的磁场的存在下，通过自由基对机制。 隐花色素磁场依赖性的计算研究的信号活动可以提供关于这种自由基对机制如何或是否可以参与鸟类磁罗盘的见解（URL：http：//www.ks.uiuc.edu/Research/cryptochrome/）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It has been suggested that the magnetic compass sense of migratory birds and some other magnetoreceptive animals may be mediated by the blue-light-receptor protein cryptochrome. Recent experiments on plant seedlings have shown that the activity of cryptochrome in Arabidopsis thaliana is enhanced by the presence of a weak external magnetic field, confirming the ability of cryptochrome to harbor magnetic field responses. Additionally, cryptochrome has been found in retinal cells of birds known to be active during orientation behavior. Cryptochromes signaling is regulated by the photoreduction of an internally bound chromophore, flavin adenine dinucleiotide (FAD). The spin chemistry of this photoreduction process, which involves electron transfer from a chain of three tryptophans, is modulated by the presence of a magnetic field via the radical pair mechanism. Computational studies of the magnetic field dependence of cryptochromes signaling activity may give insights as to how or whether this radical pair mechanism could be involved in the avian magnetic compass (URL: http://www.ks.uiuc.edu/Research/cryptochrome/).