STRUCTURAL DYNAMICS OF VIRUSES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 病毒是导致许多疾病的寄生生物。病毒由包裹在蛋白质外壳(衣壳)中的基因组组成，通常带有一些其他辅助分子。病毒感染取决于病毒粒子根据感染阶段维持其稳定性、分解或组装的能力；这些步骤由病毒组件之间的相互作用以及外部因素决定。因此，研究病毒组分的动力学对于阐明病毒感染的机制是至关重要的。虽然大量的病毒已经从结构上分解(见[1])，但静态结构不能揭示动态特性；而且，实时实验(例如[2，3])的空间和时间分辨率通常远低于区分单个病毒蛋白质运动所需的分辨率。在这种情况下，分子动力学研究非常适合作为实验的补充，因为分子动力学模拟现在能够以原子分辨率[4](http://www.ks.uiuc.edu/Research/STMV).)描述完整病毒的动力学

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Viruses are parasitic organisms responsible for many diseases. A virus consists of a genome enclosed in a protein coat (capsid), often with a few other accessory molecules. Viral infection depends on the ability of a virion to maintain its stability, disassemble, or assemble depending on the infection stage; these steps are determined by interactions between the viral components, as well as by external factors. Thus, studying the dynamics of viral components is crucial for elucidation of the mechanisms of viral infections. Although a large number of viruses have been structurally resolved (see, e.g., [1]), a static structure does not reveal dynamical properties; also, the spatial and temporal resolution of real-time experiments (e.g. [2, 3]) is usually much lower than that required to distinguish the movements of individual viral proteins. In this situation, MD studies are perfectly suited to complement experiments, as MD simulations are now capable of describing the dynamics of complete viruses at atomic resolution [4] (http://www.ks.uiuc.edu/Research/STMV).