MICROIMAGING & SPECTROSCOPY OF MUSCLE DAMAGE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在营养不良性肌病的整个进展过程中，受影响的肌肉组织由于其对损伤的高度敏感性而经历许多退化和再生循环。当这些肌肉的再生能力耗尽时，受损的纤维逐渐被脂肪和结缔组织取代。这些研究为临床前和临床体内MR研究提供了必要的基础，并解决了临床批准的血管外造影剂是否可以检测营养不良肌肉中的急性膜损伤。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Throughout the progression of dystrophic myopathies, the affected muscle tissues undergo numerous cycles of degeneration and regeneration due to their high susceptibility to injury. Upon exhaustion of the regenerative capacity of these muscles, damaged fibers are progressively replaced by fat and connective tissue. These studies provide an essential foundation for both pre-clinical and clinical in vivo MR studies and address whether clinically approved extravascular contrast agents can detect acute membrane damage in dystrophic muscle.