COGNITIVE & NEURAL IMPAIRMENT IN FRONTOTEMPORAL DEMENTIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目利用行为测试和神经成像来表征额颞叶痴呆(FTD)的认知障碍，特别关注语言语义和语法方面的神经基础，因为它适用于FTD中常见的进行性失语。这项工作的一个组成部分是研究公开演讲过程中大脑的区域激活。在公开讲话期间使用大胆的功能磁共振成像是有问题的，因为公开讲话会导致颅骨充气空洞的静态磁化率梯度出现巨大波动。相反，基于ASL的功能磁共振成像可以使用对静态敏感性效应不敏感的脉冲序列进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project utilized behavioral testing an neuroimaging to characterize cognitive impairment in frontotemporal dementia (FTD), with a specific focus on the neural basis for semantic and grammatical aspects of language as it applies to progressive aphasia that is commonly seen in FTD. One component of this effort is to study regional brain activation during overt speech. Use of BOLD fMRI during overt speech is problematic, because overt speech causes large fluctuations in static susceptibility gradients from air filled cavities in the skull. In contrast, ASL based fMRI can be carried out using pulse sequences that are insensitive to static susceptibility effects.