Exploring the brain basis of rhythm in individuals with aphasia

探索失语症患者节律的大脑基础

• 批准号: 10386555
• 负责人: Anna Victoria Kasdan
• 金额: $ 3.08万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10386555
• 关键词: Acquired Communication Disorders; Address; Affect; Age; Alpha Rhythm; Aphasia; Area; Auditory; Basal Ganglia; Basic Science; Behavioral; Brain; Brain Injuries; Brain region; Brain scan; Chronic; Clinic; Clinical; Clinical Research; Clinical Sciences; Cognitive; Communication impairment; Conflict (Psychology); Control Groups; Data Analyses; Discrimination; Disease; Elements; Empirical Research; Exhibits; Future; Goals; Heterogeneity; Impairment; Individual; Individual Differences; Inferior frontal gyrus; Knowledge; Language; Lead; Left; Lesion; Linguistics; Link; Literature; Location; Measures; Mentored Research Scientist Development Award; Methodology; Motor; Music; Neurobiology; Output; Participant; Pathologist; Patients; Pattern; Perception; Performance; Periodicity; Population; Production; Recovery; Rehabilitation therapy; Role; Speech; Stimulus; Stroke; Structure; Symptoms; Techniques; Therapeutic; Time; Tissues; Training; United States; Work; base; behavioral study; brain behavior; clinically relevant; cohort; experimental study; improved; individual variation; infancy; knowledge base; machine learning method; melodic intonation therapy; neuromechanism; post stroke; precision medicine; preservation; relating to nervous system; skills; stem; stroke-induced aphasia; therapy development; therapy outcome; trait

PROJECT SUMMARY The goal of this proposal is to characterize the neural substrates underlying rhythm abilities and the relationship with language profiles in individuals with aphasia. Aphasia is an acquired communication disorder resulting from damage to language regions of the brain, with stroke as the leading cause. Currently, over 2 million individuals in the United States are living with aphasia. Aphasia is notoriously difficult to treat and patients exhibit significant individual variability in recovery trajectories and in what therapeutic elements work best in aiding such recovery. Speech-language pathologists frequently use rhythmic elements (e.g., tapping to a beat) in the clinic in order to facilitate speech output. However, there is a lack of a deep and systematic empirical assessment of rhythm in aphasia at both a behavioral and neural level. Our first aim is to characterize the neural basis of individual differences in rhythm abilities in individuals with chronic, post-stroke aphasia. To do this, we will administer a comprehensive battery of rhythm perception and production tasks to a large cohort of individuals with aphasia and age-matched controls. We will then employ multivariate lesion-symptom mapping, a machine-learning methodology for identifying brain-behavior relationships, to determine which brain regions are associated with rhythm processing in aphasia. We hypothesize that individuals who have damage to brain regions important for rhythm, including the basal ganglia or the left inferior frontal gyrus (LIFG), will exhibit the greatest impairments in rhythm. Critically, the LIFG is a core language region typically damaged in post-stroke, non-fluent aphasia. Motivated by robust evidence for associations between rhythm and language across cognitive, neural, and behavioral domains, we will assess the relationship between rhythm and language measures in aphasia in our second aim. We predict that individuals with higher rhythm abilities will have higher language scores, particularly on measures of connected speech. This mentored training award will provide the applicant with training in advanced neural and behavioral data analysis techniques and expertise in large-scale project management with a patient cohort. With significant and timely clinical relevance, our proposal will address vital gaps in the literature by taking an individual differences approach to understanding the relationship between rhythm, the brain, and language in aphasia.

项目摘要 这项建议的目标是表征神经基板的节奏能力和基础的 与失语症患者语言特征的关系。失语症是一种后天性的交流障碍 这是由于大脑语言区域受损造成的，中风是主要原因。目前，超过2 在美国有数百万人患有失语症。失语症是出了名的难治， 患者在恢复轨迹和治疗元素的作用方面表现出显著的个体差异 最好的帮助这种复苏。语言病理学家经常使用节奏元素（例如，敲击来 节拍）以便于语音输出。然而，缺乏一个深入和系统的 在行为和神经水平上对失语症节律的经验性评估。 我们的第一个目标是描述个体节奏能力差异的神经基础， 慢性中风后失语症为了做到这一点，我们将管理一个全面的节奏感知电池， 生产任务，以一个大队列的个人与失语症和年龄匹配的控制。然后我们将雇用 多变量病变-症状映射，用于识别大脑行为的机器学习方法 关系，以确定哪些大脑区域与失语症的节奏处理相关。我们 假设对节律重要的大脑区域（包括基底节）有损伤的个体， 神经节或左额下回（LIFG）将表现出最大的节律障碍。关键是， LIFG是一个核心语言区域，通常在中风后非流利性失语症中受损。 受节奏和语言之间在认知、神经和心理方面的关联的有力证据的激励， 行为领域，我们将评估节奏和失语症的语言措施之间的关系，在我们的 第二个目标。我们预测，节奏能力越高的人，语言成绩越高， 特别是关于连接语音的测量。 这个指导培训奖将为申请人提供先进的神经和行为数据的培训 分析技术和专业知识在大型项目管理与患者队列。重要的和 及时的临床相关性，我们的建议将通过采取个体差异来解决文献中的重要空白 理解失语症中节奏、大脑和语言之间关系的方法。