Exploring the brain basis of rhythm in individuals with aphasia

项目总结 这项建议的目标是表征潜在的神经基础节奏能力和 失语症患者语言特征与语言特征的关系。失语症是一种获得性沟通障碍。 由大脑语言区域受损引起，中风是主要原因。目前，超过2 美国有数百万人患有失语症。失语症是出了名的难以治疗和 患者在康复轨迹和治疗要素的作用方面表现出显著的个体差异 在帮助这种复苏方面表现最佳。言语语言病理学家经常使用有节奏的元素(例如，敲击 A节拍)，以便于语音输出。然而，缺乏一种深入系统的研究方法。 在行为和神经水平对失语症节律的经验性评估。 我们的第一个目标是描述个体节律能力差异的神经基础。 慢性中风后失语症。为了做到这一点，我们将管理一个全面的节奏感和 将生产任务分配给大量失语症患者和年龄匹配的对照组。然后，我们将雇用 多变量病变-症状图，一种识别大脑行为的机器学习方法 关系，以确定哪些大脑区域与失语症的节奏处理有关。我们 假设脑部对节律有重要影响的区域，包括基底节律受损的个体 神经节或左下额叶回(LIFG)将表现出最大的节律障碍。关键的是， LIFG是一个核心语言区域，通常在中风后非流利失语症中受损。 受节奏和语言之间在认知、神经和语言方面的关联的强有力证据的推动 ，我们将评估失语症患者的节奏和语言测量之间的关系 第二个目标。我们预测，节奏能力较高的人语言成绩也会更高， 尤其是关于连通语音的衡量标准。 该指导培训奖将为申请者提供高级神经和行为数据方面的培训 在大型项目管理方面的分析技术和专业知识与患者队列。具有重要的和 及时的临床相关性，我们的建议将通过采取个体差异来解决文献中的重大差距 了解失语症患者节奏、大脑和语言之间关系的方法。

PROJECT SUMMARY The goal of this proposal is to characterize the neural substrates underlying rhythm abilities and the relationship with language profiles in individuals with aphasia. Aphasia is an acquired communication disorder resulting from damage to language regions of the brain, with stroke as the leading cause. Currently, over 2 million individuals in the United States are living with aphasia. Aphasia is notoriously difficult to treat and patients exhibit significant individual variability in recovery trajectories and in what therapeutic elements work best in aiding such recovery. Speech-language pathologists frequently use rhythmic elements (e.g., tapping to a beat) in the clinic in order to facilitate speech output. However, there is a lack of a deep and systematic empirical assessment of rhythm in aphasia at both a behavioral and neural level. Our first aim is to characterize the neural basis of individual differences in rhythm abilities in individuals with chronic, post-stroke aphasia. To do this, we will administer a comprehensive battery of rhythm perception and production tasks to a large cohort of individuals with aphasia and age-matched controls. We will then employ multivariate lesion-symptom mapping, a machine-learning methodology for identifying brain-behavior relationships, to determine which brain regions are associated with rhythm processing in aphasia. We hypothesize that individuals who have damage to brain regions important for rhythm, including the basal ganglia or the left inferior frontal gyrus (LIFG), will exhibit the greatest impairments in rhythm. Critically, the LIFG is a core language region typically damaged in post-stroke, non-fluent aphasia. Motivated by robust evidence for associations between rhythm and language across cognitive, neural, and behavioral domains, we will assess the relationship between rhythm and language measures in aphasia in our second aim. We predict that individuals with higher rhythm abilities will have higher language scores, particularly on measures of connected speech. This mentored training award will provide the applicant with training in advanced neural and behavioral data analysis techniques and expertise in large-scale project management with a patient cohort. With significant and timely clinical relevance, our proposal will address vital gaps in the literature by taking an individual differences approach to understanding the relationship between rhythm, the brain, and language in aphasia.