PRECLINICAL MOUSE MODELS: CENTRAL NERVOUS SYSTEM CANCERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在人类病例或各种动物模型中，对不同脑微环境中促癌病变引起的胶质细胞的性质了解甚少。加州大学圣地亚哥分校-NCMIR和MMHCC研究人员在圣地亚哥查佩尔山（货车戴克）和华盛顿大学（古特曼）的合作活动集中在两个独立的中枢神经系统癌症：星形细胞瘤和视神经胶质瘤。总的来说，我们的目标是解决与正常和肿瘤相关的神经胶质细胞的形态，分布和分子组成有关的不同问题。 我们建议使用NCMR中开发的技术来研究1肿瘤相关和瘤周胶质细胞形态，2胶质细胞分布和肿瘤内的边界，以及3与肿瘤和正常周围区域相关的分子成分分布的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Little is understood about the properties of glial cells elicited by cancer-promoting lesions in distinct brain microenvironments either in human cases or various animal models. Collaborative Activities between UC San Diego-NCMIR and MMHCC researchers at UNC Chapel Hill (Van Dyke) and Washington University (Gutmann) are centered on two separate central nervous system cancers: astrocytoma and optic glioma. Overall, our goal is to address distinct questions about the morphology, distribution and molecular constituents associated with normal, and tumor-associated glial cells. We propose to use the techniques developed in NCMIR to investigate 1 tumor-associated and peritumoral glial morphology, 2 glial cell distribution and boundaries within tumors and 3 differences in distribution of molecular constituents associated with tumor and normal surrounding areas by large scale mapping.