MECHANICS OF BLOOD FLOW IN MICROVESSELS

这个子项目是众多研究子项目之一 资源由NIH/NCRR资助的中心拨款提供。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资助， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 这个超级计算机资源提案是为了支持两个nsf资助的项目（BES-0603035和CTS-0625936）。提出的目的是建立计算流体动力学模型和模拟来研究可变形颗粒的流体动力学。重点将放在直径为10- 300 $\mu$米的微血管中多个血细胞的血流动力学上，这是典型的微循环和微流体装置。重点是考虑大量可变形血细胞（$\sim$ O(500)）的动态能力，同时解决每个细胞内部的变形和流动问题。为此，我们在NCSA使用IBM p690来开发全三维代码，使用浸入式边界方法来处理可变形单元，并结合傅里叶-有限差分格式来求解流。我们还通过简单的化学动力学方法将相邻细胞之间以及细胞与血管壁之间的分子相互作用与流体动力学结合起来。利用过去的分配，我们开发了三维代码，并解决了微血管中单个和二元可变形细胞的流体力学相关问题。我们将继续进行多细胞研究，因此请求NCSA继续支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal for supercomputer resource is to support two NSF-funded proposals awarded to the PI (BES-0603035 and CTS-0625936). Objective of the proposal is to develop computational fluid dynamic models and simulation to study the hydrodynamics of deformable particles. The focus will be on the hemodynamics of multiple blood cells in microvessels of 10--300$\mu$m diameter, typical of microcirculation and microfluidic devices. The emphasis is on the ability to consider the dynamics of a large population of deformable blood cells, $\sim$ O(500) in number, while resolving the deformation of and the flow inside each individual cell. To that end, we are using the IBM p690 at NCSA to develop fully three-dimensional code using immsersed boundary methods for deformable cells, and combined Fourier--Finite difference scheme for the flow solver. We also couple molecular interaction between the adjacent cells and between a cell and a blood vessel wall to the hydrodynamics via a simple chemical kinetic approach. Using the past allocation, we have developed the 3D code, and addressed some problems related to the hydrodynamics of single and binary deformable cells in microvessels. We continue to pursue research on multiple cells, and hence request for continued support from NCSA.