SPB LOCALIZATION OF HSL7

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在细胞周期的大部分时间里，Hsl7通过Hsl1被拴在芽颈上。有趣的是，V.Cid等人观察到在 G1，在Hsl7的S到达蕾颈之前，Hsl7定位于Spb。虽然大多数已确定的SPB组件 有明显的结构作用，几个具有调节/信号作用的蛋白质的例子，定位于这个亚细胞 结构也进行了表征。其中的一个子集包括在M期间定位于SPB的蛋白质 它们参与协调SPB的动态和后期有丝分裂事件。Hsl7基因定位于SPB的研究 在G1期间，暗示了Hsl7的一个尚未确定的角色。我们的目标是表征HSL7与SPB的结合。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hsl7 during much of the cell cycle is tethered to the bud neck via Hsl1. Interestingly, V. Cid et al., observed that during G1, prior to Hsl7's arrival at the bud neck, Hsl7 localizes to the SPB. While most of the identified components of the SPB have obvious structural roles, several examples of proteins with regulatory/signaling roles that localize to this subcellular structure have also been characterized. A subset of these include proteins that localize to the SPB specifically during M phase and are involved in coordinating SPB dynamics with late mitotic events. The finding that Hsl7 localizes to the SPB during G1 suggests a yet uncharacterized role for Hsl7. The goal is characterizing the binding of Hsl7 to the SPB.