Pulse wave velocity in chronic kidney disease

描述（由申请人提供）：美国国家糖尿病、消化和肾脏疾病研究所（NIDDK）于2001年建立了慢性肾功能不全队列研究。CRIC研究的主要目标是在不同严重程度的CKD患者中检查慢性肾脏疾病（CKD）进展（即进一步肾功能丧失）和心血管事件的危险因素，并建立预测模型，以确定CKD的高危亚组。后者的结果将针对高风险受试者纳入未来的治疗试验，并增加现有预防疗法的应用。高血压治疗是改变慢性肾病肾功能丧失过程最有效的干预措施。然而，用于治疗高血压的药物对肾功能的益处不同。这增加了一种可能性，即血压降低本身只是部分解释了它们的有益作用，并召唤了对血管适应疾病（如CKD）的更广泛理解。脉搏波速度（PWV）的测定反映了大血管的刚度，为心血管疾病流行病学提供了有用的信息。

DESCRIPTION (provided by applicant): The National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) established the Chronic Renal Insufficiency Cohort Study in 2001. The principal goals of the CRIC Study are to examine risk factors for chronic kidney disease (CKD) progression (i.e. further loss of kidney function) and cardiovascular events among patients with varying severity of CKD, and develop predictive models that will identify high-risk subgroups with CKD. The latter results will target enrollment of high-risk subjects into future treatment trials and increase application of available preventive therapies. Hypertension treatment has been the most effective intervention altering the course of renal function loss in CKD. However, the drugs used in the treatment of hypertension differ in their benefits on renal function. This raises the possibility that blood pressure reduction by itself only partly explains their beneficial effect and beckons a broader understanding of vascular adaptation to diseases such as CKD. Determination of the pulse wave velocity (PWV) a reflection of large vessel stiffness has provided useful information in cardiovascular disease epidemiology.