IMMUNE CORRELATES OF COGNITIVE FUNCTION IN SLE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究旨在探讨系统性红斑狼疮（SLE;狼疮）患者血液中的免疫指标。 具体而言，本研究将寻找血液中不同免疫标志物与SLE患者和正常对照参与者的认知障碍和记忆障碍类型之间的潜在关系。 作为母研究的一部分，SLE受试者和正常对照受试者将接受神经心理学测试，以确定SLE中的特定认知障碍。 本补充研究将包括从完成母研究的神经心理学测试预约的受试者中进行单次抽血。 血液中特定免疫参数的测量不仅将提供与正常对照相比与SLE相关的生物标志物的洞察，而且将允许识别SLE中认知功能的潜在免疫介质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is exploring immune measures in the blood of persons with systemic lupus erythematosus (SLE; Lupus). Specifically, this study will be looking for potential relationships between different immune markers in the blood and types of cognitive impairments and memory impairments in persons with SLE and normal control participants. As a part of the parent study, participants with SLE and normal control subjects will undergo neuropsychological testing that will identify particular cognitive impairments in SLE. This supplementary study will include a single blood draw from participants completing the neuropsychological testing appointment of the parent study. The measurement of particular immune parameters in the blood will not only provide insight into the biological markers that are related to SLE compared with normal controls, but will allow for the identification of potential immune mediators of cognitive function in SLE.