ANA/CAT MRKRS IN SKLETL MUSCLE IN RESP TO ANDROGEN DEPRIVATION THERAPY & EXERCIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的目标是通过保护他们的肌肉免受癌症和/或癌症治疗的影响，帮助患有癌症的老年人过上更健康，更富有成效的生活。雄激素剥夺疗法（ADT）是前列腺癌的一种常见治疗方法，可显著降低血液中性激素睾酮的水平，以保护前列腺。ADT有助于延缓前列腺癌的进展或复发，但也会导致肌肉损失。肌肉的这些变化令人不安，因为它们会导致虚弱，并可能影响生活质量。此外，男性通常被诊断患有前列腺癌的年龄（50 - 80岁）本身与肌肉质量和力量的损失有关。因此，ADT可能会导致老年人过早虚弱。我们建议，阻力运动训练（举重）可以抵消由于ADT引起的肌肉生物学变化，并导致肌肉质量增加（肥大）。在这项初步研究中，我们将确定阻力运动训练的有效性，以抵消肌肉生物学的变化，在男性谁一直在接受ADT。我们将测量特定基因的变化，这些基因对ADT和阻力运动训练中肌肉分解和生长非常重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to help older adults with cancer live healthier, more productive lives by protecting their muscles from the effects of cancer and/or cancer treatment. Androgen-deprivation therapy (ADT), a common treatment for prostate cancer, dramatically reduces the levels of the sex hormone testosterone in the blood to protect the prostate. ADT is beneficial in delaying the progression or recurrence of prostate cancer, but it also causes the loss of muscle. These changes in muscle are troubling because they cause weakness and can impair quality of life. Furthermore, the age at which men are typically diagnosed with prostate cancer (50 - 80 y) is in itself associated with a loss of muscle mass and strength. Thus, ADT may cause premature frailty in older men. We are proposing that resistance exercise training (weight lifting) can offset changes in muscle biology due to ADT and cause an increase in muscle mass (hypertrophy). In this preliminary study, we will determine the effectiveness of resistance exercise training to offset changes in muscle biology in men who have been undergoing ADT. We will measure changes in specific genes important to muscle breakdown and growth in response to ADT and resistance exercise training.