PARTIAL AND COMPLETE GROWTH HORMONE BLOCKADE IN POLYCYSTIC OVARY SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人们对多囊卵巢综合征(PCOS)知之甚少，影响了5-8%的育龄妇女，导致不孕不育，并增加了患糖尿病和心脏病的风险。这项建议的长期目标是提高对多囊卵巢综合征的病理生理学的了解，以便开发更有效的治疗方法。这项建议使用一种新的生长激素拮抗剂作为生理探针，以分离生长激素在这种复杂而鲜为人知的疾病中的作用。这项建议的短期目标是确定生长激素和IGF-1在多囊卵巢综合征患者过度胰岛素抵抗和高雄激素血症中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The poorly understood syndrome of Polycystic Ovary Syndrome (PCOS) affects 5-8% of reproductive age women and results in infertility as well as an increased risk of diabetes and heart disease. The long term objective of this proposal is to improve understanding of the pathophysiology of PCOS in order that more effective treatments can be developed. This proposal uses a new growth hormone antagonist as a physiological probe to isolate the effects of growth hormone in this complex and poorly understood disease. The short term goal of this proposal is to determine the contribution of growth hormone and IGF-1 to the excess insulin resistance and hyperandrogenism in PCOS.