GENERAL CLINICAL RESEARCH CENTER

超出提供的空间。 这是西北大学综合临床研究中心(GCRC)与之竞争的续签拨款提案 大学和西北纪念医院。GCRC自1961年以来一直得到资助，是一项 六个床位分立单元。西北大学医学院院长、医学博士刘易斯·L·兰茨伯格是新的 首席调查员。William L.Lowe，Jr.医学博士是新任命的项目主任。格哈德·P。 鲍曼博士继续担任负责核心实验室的副项目主任，而拉姆·约格夫， 医学博士和医学博士博伊德·梅茨格继续担任项目副主任，负责儿科和培训 分别进行了分析。在过去的几年里，西北大学医学院的研究活动 在临床和基础科学方面都有很大的提高。成功招聘研究型员工 儿科学、神经病学、神经外科、外科、分子药理学和物理疗法讲座 促进创造一种环境，促进GCRC目前和未来的更多利用。此次续订 应用程序包含来自37个不同主要调查人员的52项协议，这些主要调查人员代表7个部门 医学、儿科学、外科、神经外科、产科/妇科、神经病学和预防 医学)和医学部内的9个司。续签还包括延续 儿童纪念医院的卫星住院和门诊CRC设施。科学的广度是 将在现场参观时提交的协议表明。这些研究包括对遗传学和 妊娠期糖尿病的表型，使用造血干细胞移植治疗 自身免疫性疾病与血因子水平及编码血因子基因遗传变异的关系 随着外周动脉疾病的结果，P细胞移植治疗1型糖尿病的新创新 糖尿病，钠和钾代谢的种族差异，神经肌肉和 膝关节骨关节炎进展中的力学因素：潜在的年龄相关性睡眠改变的机制 以及昼夜节律和改善睡眠和白天的行为干预的有效性 神经心理学

EXCEED THE SPACE PROVIDED. This is a competing renewal grant proposal for the General ClinicalResearch Center (GCRC) at Northwestern University and Northwestern Memorial Hospital. The GCRC has been continuouslyfunded since 1961 and is a six bed discrete unit. Lewis L. Landsberg, MD, Dean of Northwestern University Medical School, is the new Principal Investigator. William L. Lowe, Jr., MD is the newly appointed Program Director. Gerhard P. Baumann, MD continues as Associate Program Director responsible for the Core Laboratory, while Ram Yogev, MD and Boyd Metzger, MD continue as Associate Program Directors, responsible for Pediatrics and Training respectively. Over the past few years, research activities at Northwestern University Medical School have increased substantiallyboth in the clinical and the basic sciences. Successful recruitments of research-oriented Chairs of Pediatrics, Neurology, Neurological Surgery, Surgery, Molecular Pharmacology, and Physical Therapy contribute to an environment that fosters the current and future increased utilization of the GCRC. This renewal application contains 52 protocols from 37 different principal investigators representing 7 Departments (Medicine, Pediatrics, Surgery, Neurological Surgery, Obstetrics/Gynecology, Neurology, and Preventive Medicine), and 9 divisions within the Department of Medicine. The renewal also includes a continuation of the satellite inpatient and outpatient CRC facilities at Children's Memorial Hospital. The breadth of science is demonstrated by the protocols to be presented at the Site Visit. These include studies of the genetics and phenotype of gestational diabetes mellitus, use of hematopoietic stem cell transplantation for the treatment of autoimmune diseases, association of blood factor levels and genetic variations of genes encoding blood factors with peripheral arterial disease outcome, new innovations in P-cell transplantation for the treatment of type 1 diabetes mellitus, racial differences in the metabolism of sodium and potassium, role of neuromuscular and mechanical factors in knee osteoarthritis progression, the mechanismsof underlying age-related changes in sleep and circadian rhythmsand the effectiveness of behavioral interventions to improve sleep anddaytime neuropsychological