EXERCISE AND POLYPOSIS IN THE APCMIN/+ MOUSE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 博士卡森的项目研究了运动减少癌症易感ApcMin/+小鼠息肉形成的机制。 评估了影响的机制。 此外，该项目还研究了恶病质的过程，即，肌肉和脂肪损失，在老化ApcMin/+小鼠。 促进恶病质的细胞和分子因子，如炎性细胞因子（白细胞介素-6）和信号分子，正在被检查作为恶病质的介质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Carson's project examines the mechanisms by which exercise reduces polyp formation in the cancer-predisposed ApcMin/+ mouse. Mechanisms of the effects are assessed. In addition, the project examines the cachexic process, i.e., muscle and fat loss, in aging ApcMin/+ mice. Cellular and molecular factors promoting cachexia, such as inflammatory cytokines (interleukin-6) and signaling molecules, are being examined as mediators of cachexia.