IMPACT OF CALCIUM INTAKE ON BODY COMPOSITION AND BLOOD LIPIDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 超重和肥胖是波多黎各的主要公共卫生问题，影响了超过60%的人口。最近的临床研究表明，高钙摄入量可以显著降低肥胖者的体重、脂肪质量和血脂。目前还不清楚这种影响是由于乳制品中的钙还是其他成分造成的，也不清楚这些影响是否出现在拉美裔人群中。我们建议进行这项研究，以检验高钙摄入量会导致一组肥胖波多黎各成年人的身体成分和血脂发生变化的假设。我们进一步假设，在一组肥胖的波多黎各成年人中，乳制品钙摄入量比元素钙和元素钙摄入量对身体成分和血脂更有效。将30名受试者随机分为对照组或低乳品组(每日钙700 mg)、高乳钙组(每日补钙1300 mg)和高元素钙组(每日补钙1300 mg)，为期6个月。通常的营养素摄入量和体力活动最初将从3天的记录中估计出来。在研究过程中，受试者将根据这些估计值计算等卡路里饮食。受试者将被要求保持他们的体力活动水平不变。在研究开始和结束时，将通过双能X射线吸收法测量身体成分，每月通过人体测量测量身体成分。血脂将在研究开始和结束时进行测量。如果增加乳制品和/或元素clacium的摄入量导致这组肥胖者的身体成分和血脂发生积极变化，那么增加习惯性的钙摄入量将显著影响肥胖症和其他疾病的治疗。还需要进一步的研究来证实这些结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overweight and obesity are major public health problems in Puerto Rico, affecting more than 60% of the population. Recent clinical research has shown that a high calcium intake can significantly reduce body weight, fat mass, and blood lipids in obese indivuduals. It is unclear whether this effect is due to calcium alone or to other constituents in dairy products and if these effects are seen in the Hispanics population. We propose to do this study to test the hypothesis that a high calcium intake leads to changes in body composition and blood lipids in a group of obese Puerto Rican adults. We further hypothesize that dairy calcium intake is more effective that elemental calcium and elemental calcium intake on body composition and blood lipids in a group of obese Puerto Rican adults. Thirty subjects will be randomized into a treatment groups for 6 months: a control group or low dairy group (700mg/d of calcium), a high dairy calcium group (1300 mg/d of calcium) and a high elemental calcium group (1300 mg/d of calcium). Usual nutrient intake and physical activity will be estimated initially from 3-day records. Isocaloric diets will be calculated from these estimates for subjects to follow during the course of the study. Subjetcs will be asked to maintain their level of physical activity constant. Body composition will be measured at the beginning and the end of the study by dual-energy x-ray absorptiometry and monthly by anthropometric measurements. Blood lipids will be measured at the beginning and at the end of the study. If increasing dairy and/or elemental clacium intake leads to positive changes in body composition and blood lipids in this group of obese subjects, then increasing habitual calcium intake would significantly impact the treatment of obesity, as well as other diseases. Further studies will be needed to confirm these results.