GENETIC LINKAGE STUDIES OF ASTHMA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 哮喘是一种常见的疾病，是由许多基因和环境因素之间复杂的相互作用引起的。我们研究的总体目标是确定影响哮喘和哮喘相关表型风险的基因。这些研究将集中于在芝加哥招募的哮喘病例和对照，代表两个种族群体：非洲裔美国人和高加索人。所有哮喘病例将根据肺功能、支气管高反应性、气道可逆性、气道炎症和特应性进行表征。对照组是没有哮喘的个人或一级亲属的成年人，并将在肺功能、气道炎症和特应性方面进行表征。我们将使用候选基因和全基因组方法来鉴定与哮喘和相关表型相关的基因以及这些基因中的变异。确定哮喘易感性基因可能通过确定发病机制中涉及的新生化途径并允许开发定制的药物干预措施来对健康产生重大影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a common disease that is caused by complex interactions between many genes and environmental factors. The overall goal of our study is to identify genes that influence risk for asthma and asthma-associated phenotypes. These studies will focus on asthma cases and controls recruited in Chicago and representing two racial groups: African American and Caucasian. All asthma cases will be characterized with respect to lung function, bronchial hyperreactivity, airway reversibility, airway inflammation, and atopy. Controls are adults without a personal or first degree relative with asthma, and will be characterized with respect to lung function, airway inflammation, and atopy. We will use both candidate gene and genome-wide approaches to identify genes, and variation within those genes, that are associated with asthma and related phenotypes. Identifying genes that confer susceptibility to asthma can potentially have major health impact by identifying new biochemical pathways involved in pathogenesis and allowing for the development of custom tailored pharmaceutical interventions.