VAP GENETICS STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 呼吸机相关性肺炎（VAP）是重症监护病房院内感染的主要死亡原因。 VAP的发病率范围为9%至65%，取决于研究的临床亚组和使用的诊断标准。 VAP的粗死亡率高达70%，归因死亡率为30- 50%。 呼吸机相关性肺炎风险的遗传变异性知之甚少。 在这项研究中，我们建议评估PON 2基因多态性是否与呼吸机相关性肺炎的发生有关。 我们检验了这样一个假设，即发生VAP的受试者与那些接受插管且未发生这种并发症的受试者相比，CC基因型的频率更高。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ventilator-associated pneumonia (VAP) is the leading cause of death among nosocomial infections in the intensive care unit. The incidence of VAP ranges from 9% to 65% depending on the clinical subgroups studied and the diagnostic criteria used. The crude mortality rates from VAP have been found to be as high as 70%, with attributable mortality ranging from 30-50%. Little is know about the genetic variability of risk for ventilator-associated pneumonia. In this study we propose to assess if genetic polymorphisms in PON2 are associated with the development of ventilator-associated pneumonia. We tested the hypothesis that subjects who develop VAP will have a higher frequency of the CC genotype at the site compared with those who get intubated and do not develop this complication.