EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肌萎缩侧索硬化症(Lou Gehrig‘s Disease，ALS)是一种进展性疾病，无法治愈，治疗效果甚微。临床经验表明，患者通过减少肌肉质量来减肥，也通过减少卡路里摄入量来减肥。假设：充足的营养可能对生存有积极的影响。目前已有一组衡量全球肌萎缩侧索硬化症进展的量化指标，但还没有开发出类似的指标来评估营养状况。目的：开发和验证从前瞻性数据中确定能量平衡的方法，这些方法将适用于未来的营养和无创呼吸机的多中心第三阶段研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ALS (Lou Gehrig's Disease) is a progressive disease with no cure and minimally effect treatment. Clinical experience indicates that patients lose weight from loss of muscle mass, but also from reduced caloric intake. Hypothesis: Adequate nutrition may have a positive impact on survival. A group of measures are available as quantitative indices of global ALS progression, but similar measures have not been developed to evaluate nutritional status. Objective: Develop and validate methods from prospective data to determine energy balance that will be applicable in a future multicenter Phase III study of nutrition and non-invasive ventilation.