LONGITUDINAL STUDIES OF PARKINSON'S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 1)识别、招募、临床特征和纵向跟踪直至死亡的特发性帕金森病(PD)患者和同意最终尸检的健康对照，从而为神经病理学核心和PD研究中心(PDRC)项目#1-4中的神经病理学研究提供材料。临床特征将包括对帕金森病的运动、认知和精神特征的评估。将对控制措施进行可比评估。 2.)临床核心中心将与PDRC的行政核心和生物统计学家一起，开发和维护关于参与对象的所有临床数据的计算机化数据库，并使用这些信息为中心的研究提供持续的质量控制和统计支持。这些数据也将提供给JHMI的调查人员。 3.)为帕金森病临床研究计划提供基础设施，促进独立资助的帕金森病临床和临床病理研究，并协调临床核心的语言评估与受试者参与这些额外研究。 4.)培训内科科学家对帕金森病患者及相关疾病的临床评估和管理，以及帕金森病临床研究的表现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1.) To identify, recruit, characterize clinically, and follow longitudinally until death patients with idiopathic Parkinson's Disease (PD) and healthy controls who consent to eventual autopsy, thereby providing material for the Neuropathology Core and the neuropathologic studies in Projects #1-4 of the PD Research Center (PDRC). Clinical characterization will involve assessment of the motor, cognitive, and psychiatric features of PD. Comparable assessments will be conducted on controls. 2.) In conjunction with the Administrative Core of the PDRC and the biostatistician, the Clinical Core will develop and maintain a computerized database of all clnical data obtained on participating subjects, and provide ongoing quality control and statisical support for studies in the Center gran using this information. These data will also be available to investigators with JHMI. 3.) To provide the fundamental infrastructure for a clinical research program on PD that facilitates independently funded clinical and clinical pathologica investigations of PD, and to coordinate the lingicudinal assessments by the Clinical Core with subject participation in these additional studies. 4.) To train physician-scientists in the clinical assessment and managment of patients with PD and related disorders and the performance of clinical research on PD.