LONGITUDINAL STUDIES OF PARKINSON'S DISEASE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1.) To identify, recruit, characterize clinically, and follow longitudinally until death patients with idiopathic Parkinson's Disease (PD) and healthy controls who consent to eventual autopsy, thereby providing material for the Neuropathology Core and the neuropathologic studies in Projects #1-4 of the PD Research Center (PDRC). Clinical characterization will involve assessment of the motor, cognitive, and psychiatric features of PD. Comparable assessments will be conducted on controls. 2.) In conjunction with the Administrative Core of the PDRC and the biostatistician, the Clinical Core will develop and maintain a computerized database of all clnical data obtained on participating subjects, and provide ongoing quality control and statisical support for studies in the Center gran using this information. These data will also be available to investigators with JHMI. 3.) To provide the fundamental infrastructure for a clinical research program on PD that facilitates independently funded clinical and clinical pathologica investigations of PD, and to coordinate the lingicudinal assessments by the Clinical Core with subject participation in these additional studies. 4.) To train physician-scientists in the clinical assessment and managment of patients with PD and related disorders and the performance of clinical research on PD.