Immunobiology of Blood and Vascular Systems Training

描述(由申请人提供)： 该提案要求继续支持范德比尔特大学医学中心以血液和血管系统免疫生物学(IBVS)为重点的跨学科培训计划。IBVS培训计划为指导和发展对学习兴趣浓厚的本科生、研究生和博士后研究员的职业生涯提供了强有力的框架。调节人类血液和血管紊乱的炎症和自身免疫的分子方面。来自Vanderbilt微生物学和免疫学、细胞和发育生物学、医学、病理学和药理学系的21名教员将互动，以支持IBVS培训计划。大量卓有成效的合作和出版物证明，这些教职教师组成了一个高度互动的团队，在影响健康和疾病中血液和血管系统的分子机制方面具有互补的研究兴趣。他们重叠的研究领域包括(1)炎症和自身免疫的功能基因组和蛋白质组学，(2)天然免疫和炎症，(3)抗原处理和呈递，(4)淋巴细胞信号和基因表达，(5)逆转录病毒和免疫系统之间的功能相互作用，(6)淋巴细胞发育和分化，(7)抗原受体多样性的产生，(8)氧化应激和自身免疫，(9)造血细胞黏附和运输，(10)肽/蛋白质递送，以及亚细胞靶向。为了支持这些方面的创新培训，该应用程序请求支持5个博士后、5个博士后和6个本科生培训名额。将这种平衡的人才组合集中在IBVS培训计划的框架下，将创造独特的交叉受精机会，进一步加强其三个组成培训小组的研究经验和职业发展。被范德比尔特跨学科研究生计划(IGP)录取的博士前实习生将有资格获得IBVS培训计划支持，等待IBVS培训计划指导委员会对他们第一年的研究生学习进行评估。拥有博士和/或医学博士学位的博士后实习生将被任命，等待一名参与教授的提名和IBVS培训计划指导委员会的决定。为了帮助培养下一代年轻的生物医学科学家，合格的本科生将被选为IBVS培训计划的实习生参加夏季研究计划。IBVS培训计划的所有学员都将参加结构化的教学课程，包括该计划的旗舰课程“功能基因组学和蛋白质组学：免疫生物学的应用”、每周一次的“正在进行的研究”系列研讨会，以及由参加IBVS培训计划的教员领导的期刊俱乐部。

DESCRIPTION (provided by the applicant): This proposal requests continued support for an interdisciplinary training program focused on the Immunobiology of Blood and Vascular Systems (IBVS) at Vanderbilt University Medical Center. The IBVS Training Program provides strong framework for mentoring and developing the careers of undergraduates, graduate students, and postdoctoral fellows with keen interest in studying the. molecular aspects of inflammation and autoimmunity that mediate human blood and vascular disorders. Twenty-one faculty preceptors from Vanderbilt's Departments of Microbiology and Immunology, Cell and Developmental Biology, Medicine, Pathology, and Pharmacology will interact to sustain the IBVS Training Program. As evidenced by a significant number of fruitful collaborations and publications, these faculty preceptors constitute a highly interactive team with complementary research interests in the molecular mechanisms affecting the blood and vascular system in health and disease. Their overlapping research fronts encompass (1) functional genomics and proteomics of inflammation and autoimmunity, (2) innate immunity and inflammation, (3) antigen processing and presentation, (4) lymphocyte signaling and gene expression, (5) functional interplay between retroviruses and the immune system, (6) lymphocyte development and differentiation, (7) generation of antigen receptor diversity, (8) oxidative stress and autoimmunity, (9) hemopoietic cell adhesion and trafficking, and (10) peptide/protein delivery, and subcellular targeting. To support innovative training in these fronts, the application requests support for 5 predoctoral, 5 postdoctoral, and 6 undergraduate student training slots. Bringing this balanced mix of talent together under the rubric of the IBVS Training Program will create unique opportunities for cross-fertilization that further enhance the research experience and career development of its three constituent training groups. Predoctoral trainees accepted by the Vanderbilt Interdisciplinary Graduate Program (IGP) will be eligible for IBVS Training Program support pending evaluation of their first year of graduate studies by the IBVS Training Program Steering Committee. Postdoctoral trainees holding Ph.D. and/or M.D. degrees will be appointed pending nomination by a participating preceptor and the decision of the IBVS Training Program Steering Committee. To help foster the next generation of young biomedical scientists, qualified undergraduate students will be selected to participate as IBVS Training Program trainees in a summer research program. All trainees in the IBVS Training Program will be expected to participate in structured didactic offerings, including the Program's flagship course "Functional Genomics and Proteomics: Applications to Immunobiology", a weekly Research- In-Progress seminar series, and a journal club led by participating IBVS Training Program faculty preceptors.