Sleep-directed hypnosis as a complement to CPT in treating PTSD

描述（由申请人提供）：本提案旨在测试睡眠导向催眠作为现有经验支持的社会心理干预，认知加工疗法（CPT）的补充的有效性，在患有创伤后应激障碍的女性人际暴力幸存者样本中。此外，本建议旨在确定治疗中导致症状改善、更大功能领域改善和健康相关问题的作用机制。为此，将实施多方法、多模式的评估，包括精神病学、心理学和心理生理学领域的日常和间歇性监测。具体来说，40名受试者将被随机分配到催眠+ CPT （hypCPT）组或症状监测组（监测3周以控制时间的流逝和症状监测的任何潜在影响）加CPTactive对照组（CPTac）。本研究的参与者将接受一系列访谈和自我报告措施，包括1。临床医师管理PTSD量表(2)DSM-IV轴I障碍的结构化临床访谈，3。标准化创伤访谈，4。)创伤后应激障碍诊断量表，贝克抑郁量表- II， 6。Pennebaker边缘性记忆量表（英文版）；SF-36健康调查，8)。生活质量调查，9.)社会适应量表、匹兹堡睡眠质量指数及失眠严重程度指数。此外，生理指标将用于评估睡眠障碍与过度觉醒之间的关系以及生理反应性随时间的变化。精神运动警觉性任务也将被执行，以测试睡眠剥夺的存在。“嗜睡”（通过反应时间来衡量）以及随时间的相关变化。受试者将通过使用每日日记来监测症状和日常压力源，并在治疗前、治疗后和三个月随访时接受正式评估。开展这项拟议的研究将对在受创伤人群中利用一种新的方法——催眠疗法来补救睡眠障碍（PTSD最常被报道的症状之一，也是最难治疗的症状之一）具有重要意义。同时，本建议旨在阐明催眠的作用机制，催眠是一种未被充分研究的补充治疗元素，在创伤文献中几乎没有经验支持。

DESCRIPTION (provided by applicant): This proposal seeks to test the efficacy of sleep-directed hypnosis as a complement to an existing empirically supported psychosocial intervention, Cognitive Processing Therapy (CPT) in sample of female survivors of interpersonal violence suffering from PTSD. Further, this proposal seeks to identify mechanisms of action in the therapy that lead to symptom modification, improvement in larger domains of functioning, and health-related concerns. Towards this end, a multi-method, multimodal assessment will be administered including daily and intermittent monitoring across psychiatric, psychological, and psychophysiological domains. Specifically, forty subjects will be randomly assigned to either a hypnosis + CPT (hypCPT) condition or to a symptom monitoring (3 weeks of monitoring to control for the passage of time and any potential effects of symptom monitoring) plus CPTactive control group (CPTac). Participants in this study will be administered a battery of interviews and self-report measures including the 1.) Clinician Administered PTSD Scale, 2.) Structured Clinical Interview for DSM-IV Axis I Disorders, 3.) Standardized Trauma Interview, 4.) PTSD Diagnostic Scale, 5) Beck Depression Inventory - II, 6.) Pennebaker Inventory of Limbic Landuigness, 7.) The SF-36 Health Survey, 8.) Quality of Life Inventory, 9.) Social Adjustment Scale, 10) Pittsburgh Sleep Quality Index, and the 11) Insomnia Severity Index. In addition, physiological indices will be used to assess the relationship between sleep impairment and hyperarousal as well as changes over time in physiological reactivity. A Psychomotor Vigilance Task will also be administered to test for the presence of sleep deprivation (i.e. "sleepiness" as measured by reaction time) as well as related changes over time. Subjects will monitor symptoms and daily stressors through the use of daily diaries as well as undergo formal assessments at pre-treatment, post- treatment and three month follow-up points. Conducting the proposed study will have important implications on remediating sleep impairment (the most often reported symptom of PTSD and one of the most refractory to treatment) utilizing a novel approach, the addition of hypnosis, within a traumatized population. Concurrently this proposal aims to illuminate the mechanisms of action in hypnosis, an understudied complementary treatment element with virtually no empirical support in the trauma literature.