Neurovascular Control in Postural Tachycardia Syndrome (POTS)
Neurovascular Control in Postural Tachycardia Syndrome (POTS)
批准号:
7640798
负责人:
MICHAEL J JOYNER
金额:
$24.86万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-08-01 至 2010-07-31
关键词:
AddressAdrenergic AgentsAutonomic nervous system disordersBaroreflexBlood PressureBlood flowCardiac OutputCardiovascular systemEquilibriumExerciseFc ReceptorGoalsHeart RateHumanImpairmentLimb structureMediatingMusclePatientsPeripheralReflex actionRestStressSyndromeTachycardiaTestingVasoconstrictor AgentsVasodilationadrenergicfallspressureresponserestraintvasoconstriction
中文摘要
项目3的总体目标是探索人类自主神经紊乱的心血管控制机制。
在这个周期中,我们的重点将是确定体位性直立性心动过速综合征(POTS)是否
与静息和运动时血管收缩功能的基本改变有关。我们的专业
假设a)肾上腺素能血管收缩在POTS中被钝化,b)心输出量,但不是血压,
POTS患者在运动过程中会正常升高,c)交感神经抑制血流转为活跃
在花盆里肌肉将会消失。这些损伤加在一起会引起心率的过度反射增加。
在POTS患者的立位应激或动态运动期间。
英文摘要
The overall goal of project 3 is to explore cardiovascular control mechanisms in human autonomic disorders.
Our focus during this cycle will be to determine if the Postural Orthostatic Tachycardia Syndrome (POTS) is
associated with fundamental alterations in vasoconstrictor function at rest and during exercise. Our major
hypotheses are that a) adrenergic vasoconstriction is blunted in POTS, b) cardiac output, but not blood pressure,
will rise normally during exercise in patients with POTS, and c) sympathetic restraint of blood flow to active
muscles will be absent in POTS. Together these impairments will evoke excessive reflex increases in heart rate
during orthostatic stress or dynamic exercise in patients with POTS.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Variant Hemoglobin and Cardiorespiratory Regulation in Humans
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批准号:10320441
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项目类别:
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资助金额:$80.62万
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财政年份:2018
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负责人:MICHAEL J JOYNER
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依托单位:
Variant Hemoglobin and Cardiorespiratory Regulation in Humans
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批准号:10532798
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项目类别:
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资助金额:$80.62万
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财政年份:2018
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负责人:MICHAEL J JOYNER
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依托单位:
Variant Hemoglobin and Cardiorespiratory Regulation in Humans
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批准号:10065009
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项目类别:
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资助金额:$80.62万
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财政年份:2018
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负责人:MICHAEL J JOYNER
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依托单位:
Perfusion of Active Muscles: Metabolites and Nerves
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批准号:7822178
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项目类别:
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资助金额:$1.12万
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财政年份:2009
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:8710314
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项目类别:
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资助金额:$40.68万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:8307651
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项目类别:
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资助金额:$4.76万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:8532123
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项目类别:
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资助金额:$38.9万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:8879184
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项目类别:
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资助金额:$40.88万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:9086411
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项目类别:
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资助金额:$41.51万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:7650301
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项目类别:
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资助金额:$37.52万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:7882356
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项目类别:
-
资助金额:$37.26万
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财政年份:2007
-
负责人:MICHAEL J JOYNER
-
依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:7439200
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项目类别:
-
资助金额:$37.78万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:7323022
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项目类别:
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资助金额:$37.78万
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财政年份:2007
-
负责人:MICHAEL J JOYNER
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依托单位:
Neurovascular Control and Blood Pressure Regulation in Humans
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批准号:8113658
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项目类别:
-
资助金额:$4.45万
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财政年份:2007
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负责人:MICHAEL J JOYNER
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依托单位:
PERFUSION OF ACTIVE MUSCLES: METABOLITES AND NERVES
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批准号:7206057
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项目类别:
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资助金额:$4.08万
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财政年份:2005
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负责人:MICHAEL J JOYNER
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依托单位:
CALIBRATION OF GAS EXCHANGE EQUIPMENT IN THE GCRC EXERCISE LAB
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批准号:7206056
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项目类别:
-
资助金额:$0.07万
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财政年份:2005
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负责人:MICHAEL J JOYNER
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依托单位:
GENETIC POLYMORPHISM OF THE B2-ADRENERGIC RECEPTOR AND FOREARM BLOOD
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批准号:7206066
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项目类别:
-
资助金额:$1.97万
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财政年份:2005
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负责人:MICHAEL J JOYNER
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依托单位:
BETA 2 RECEPTOR POLYMORPHISMS AND LIPOLYSIS IN HUMANS
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批准号:7206132
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项目类别:
-
资助金额:$1.99万
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财政年份:2005
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负责人:MICHAEL J JOYNER
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依托单位:
VASOCONSTRICTOR AND VASODILATOR TONE IN NORMOTENSIVE HUMANS
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批准号:7206232
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项目类别:
-
资助金额:$0.5万
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财政年份:2005
-
负责人:MICHAEL J JOYNER
-
依托单位:
Neurovascular Control in Postural Tachycardia Syndrome (POTS)
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批准号:6901517
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项目类别:
-
资助金额:$26.08万
-
财政年份:2005
-
负责人:MICHAEL J JOYNER
-
依托单位:
海外基金