Signal Transduction in Neuron Migration & Axon Guidance

描述（由申请人提供）：这是一个项目项目的第一个竞争性更新申请，旨在支持和扩展专注于控制神经元过程定向生长和神经元细胞定向运动的信号机制的相互作用。这两种特性对神经元的功能至关重要，因为神经元的精确位置及其轴突和树突的适当连接是所有神经元信号传导和可塑性的基础。神经元迁移的异常模式与人类神经系统疾病有关，如智力低下、癫痫和阅读障碍，而先天性智力低下的疾病越来越多地被认为是轴突和树突连接的主要障碍。项目1由克里斯托弗·沃尔什（Christopher Walsh）领导，重点分析基于人类基因研究的与神经元迁移和过程生长有关的基因。项目3由John Flanagan牵头，主要研究神经引导因子在动物模型中的作用机制。由davvie Van Vactor领导的项目2主要分析果蝇轴突引导的控制基因，其中一些与人类疾病基因相对应。有两个核心，其中一个专门用于支持最先进的成像。

DESCRIPTION (provided by applicant): This is the first competing renewal application for a Program Project to support and expand interactions that focus on the signaling mechanisms that control the directed outgrowth of neuronal processes and the directed movement of neuronal cells. Together these two properties are essential to neuronal function, since the precise location of neurons and proper interconnection of their axons and dendrites underpins all neuronal signaling and plasticity. Abnormal patterns of neuronal migration have been implicated in human neurological disorders associated with mental retardation, epilepsy, and dyslexia, while congenital disorders of mental retardation are increasingly recognized as having major disorders of axonal and dendritic connections. Project 1, headed by Christopher Walsh, focuses on the analysis of genes implicated in neuronal migration and process outgrowth based on human genetic studies. Project 3, headed by John Flanagan, focuses on mechanisms of action of neural guidance factors in animal models. Project 2, headed by Davie Van Vactor, focuses on analysis of genes that control axon guidance in Drosphila, some of which correspond to human disease genes. There are two cores, one of which is dedicated to supporting state-of-the-art imaging.